Research in Drug Development (RD3)

Pharmacognosy Bioanalysis and Drug Discovery


My research are focused on :

His main research interests focus on chemometrics for multivariate analysis of data matrices obtained with hyphenated and spectroscopic techniques in different fields of life science.



Garrido Frenich, M. Martínez Galera, J.L. Martínez Vidal, D.L. Massart, J.R. Torres-Lapasío, K. De Braekeleer, Ji-Hong Wang and P.K. Hopke, Resolution of multicomponent peaks by multicomponent projection approach, positive matrix factorization and alternating least squares, Analytica Chimica Acta, 411 (2000) 145-155.


K. De Braekeleer, A. De Juan, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, P. Dunn and D.L. Massart, Determination of the end point of a chemical synthesis process using on-line measured mid-infrared spectra, Applied Spectroscopy 54 (2000) 601-607.


K. De Braekeleer, J.R. Torres-Lapasío and D.L. Massart, Improved purity assessment of high-performance liquid chromatography diode array detection data for overcoming the presence of the non-linearity artefact, Chemometrics and Intelligent Laboratory Systems 52 (2000) 45-59.


Garrido Frenich, J.R. Torres-Lapasío, K. De Braekeleer, D.L. Massart, J.L. Martínez Vidal and M. Martínez Galera, Application of several modified peak purity assays to real complex multicomponent mixtures by high-performance liquid chromatography with diode-array detection, Journal of Chromatography A, 855 (1999) 487-499.


K. De Braekeleer, R. De Maesschalck, P.A. Hailey, D.C.A. Sharp and D.L. Massart, On-line application of the orthogonal projection approach (OPA) and the soft independent modelling of class analogy approach (SIMCA) for the detection of the end point of a polymorph conversion reaction, by near infrared spectroscopy (NIR), Chemometrics and Intelligent Laboratory Systems, 46 (1999) 103-116.


Y. Vander Heyden, K. De Braekeleer, Y. Zhu, E. Roets, J. Hoogmartens, J. De Beer and D.L. Massart, Nested Designs in Ruggedness testing, Journal of Pharmaceutical and Biomedical Analysis, 20 (1999) 875-887.


K. De Braekeleer, A. De Juan and D.L. Massart, Purity assessment and resolution of tetracycline hydrochloride samples using high-performance liquid chromatography with diode array detection, Journal of Chromatography A, 832 (1998) 67-86.


K. De Braekeleer, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, A.J. Pettman and D.L. Massart, Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modelling mixture analysis, Journal of Biomedical and Pharmaceutical Analysis, 17 (1998) 141-152.


K. De Braekeleer and D.L. Massart, Evaluation of the orthogonal projection approach (OPA) and the SIMPLISMA approach on the Windig standard spectral data sets, chemometrics and Intelligent Laboratory Systems, 39 (1997) 127-141.


V. Vanheusden, K. De Braekeleer, J. Corthout, Ethinylestradiol and levonorgestrel preparations on the Belgian market: A comparative study, Farmaceutisch Tijdschrift voor België, Nr 1, maart 2012.

Kris De Braekeleer


Faculté de Pharmacie

tel 02 650 5239,

Campus de la Plaine

ULB CP205/06, boulevard du Triomphe, 1050 Bruxelles


2016-... Professor

2001–2016 : Manager of a laboratory division (AAS/AES, UV-VIS spectroscopy, UPLC, HPLC, Dissolution tests) in the Belgian pharmacist’s post-marketing control laboratory (Dienst voor Geneesmiddelenonderzoek / Service de Contrôle des Médicaments)

1999-2001 : Post-doc at Pfizer Global Research and Development, Sandwich, Kent, U.K. Chemometric techniques (Multivariate Curve Resolution) applied on data recorded with hyphenated techniques (HPLC-DAD, HPLC-DAD_MS) and spectroscopic techniques (Near infrared spectra)

1995-1999 : Assistant in the Department of Analytical Chemistry and Pharmaceutical technology (VUB)

1995-1999 : PhD in Pharmaceutical Sciences, (Title : « Multivariate Techniques for Purity Assessment and Pharmaceutical Reaction Monitoring » ), Department of Analytical Chemistry and Pharmaceutical Technology (VUB)

1997 (15-31 July) : Research stage (HPLC-DAD data analysis with Multivariate Curve Resolution) at the Department of Analytical Chemistry at the University of Barcelona

1995-1998 : Doctoral training in Pharmaceutical Sciences (VUB)

1991-1995 : Pharmacist graduated with great disdinction at the Free University of Brussels (VUB, Belgium)