ChOP
Service de Chimie Organique et Photochimie
Faculté des Sciences
 Pr. Andrée KIRSCH-DE MESMAEKER

Adresse:

Membres de l'unité:
 
 
 
 
Membres
Fonction
Titre
Pr Andrée 
KIRSCH-DE MESMAEKER
Tel: +32-(0)2-650.30.17.
Fax: +32-(0)2-650.30.18
Email: akirsch@ulb.ac.be
Directeur du service - Directeur et Promoteur des projets
 Professeur Ordinaire
 Université Libre de Bruxelles 
Pr Cécile MOUCHERON 
Tel: +32-(0)2-650.36.07.
Fax: +32-(0)2-650.30.18
Email: cmouche@ulb.ac.be
Responsable du laboratoire 
Promoteur des projets
  Chargé de cours
 Université Libre de Bruxelles
Ing. Vandeloise Robert
Tel: +32-(0)2-650.36.24.
Fax: +32-(0)2-650.3018
Email:rvdelois@ulb.ac.be
Conception de matériel en relation avec les thèmes de recherche du service.
Assistance technique
Ingénieur Industriel Principal
Me Rita LAREPPE
Tel: +32-(0)2-650.20.99
Fax: +32-(0)2-650.3018
Email: rlareppe@ulb.ac.be
 Secrétariat du service
Secrétaire
Dr  Frédéric PIERARD
Tel: +32-(0)2-650.66.39
Fax: +32-(0)2-650.3018
Email: frpierard@ulb.ac.be
Post doctorant
Sujet:
Etude de réseaux constitués d'oligonucléotides fonctionnalisés par de complexex de Ru(II) et d'Os (II)
Docteur 
Dr Stéphane RICKLING
Tel: +32-(0)2-650.29.27
Fax: +32-(0)2-650.30.18
Email: stephane.rickling@ulb.ac.be
Post doctorant
Sujet:
Photochimie de complexes de métaux de transition en présence de télomères
Docteur 
Dr  Sabrina AURY
Tel: +32-(0)2-650.66.39
Fax: +32-(0)2-650.30.18
Email: Sabrina.Aury@ulb.ac.be
Post doctorant
Sujet:
Etude photochimique du Ru (II) en présence d'oligonucléotides et oligopeptides
Docteur 
Dr  Larisa MOKHIR
Tel: +32-(0)2-650.66.39
Fax: +32-(0)2-650.30.18
Email: lmokhir@ulb.ac.be
Post doctorant
Sujet:
Photosondes d'association ADN/polymmères,  agents de vectorisation dans les cellules
Docteur 
Dr Etienne GICQUEL
Tel: +32-(0)2-650.66.40
Fax: +32-(0)2-650.30.18
Email: egicquel@ulb.ac.be
Post doctorant
Sujet:
Photoréactivité  de complexes du Ru (II) en présence d'acides aminés et d'oligopeptides
Docteur 
Mr Arnaud BOISDENGHIEN
Tel: +32-(0)2-650.25.27.
Fax: +32-(0)2-650.30.18.
Email: aboiden@ulb.ac.be
Doctorant
Sujet: 
Photo-physique de complexes du Ru (II) intercalants en présence d'ADN.
Photoréactivité de complexes du Ru (II) en présence d'acides aminés.
Assistant
Licencié en chimie
Mr Benjamin ELIAS
Tel: +32-(0)2-650.25.27.
Fax: +32-(0)2-650.30.18
Email: beelias@ulb.ac.be
Doctorant
Sujet: 
Synthèse et photophysique de complexes de Ru(II) mono- et dinucléaires en présence d'ADN
Assistant
Licencié en chimie
Melle Stéphanie DEROO 
Tel: +32-(0)2-650.66.40
Fax: +32-(0)2-650.30.18
Email: sderoo@ulb.ac.be
Doctorante
Sujet: 
Etude photophysique et photochimie de complexes du Ru(II) fonctionnalisés en présence d'oligonucléotides et d'acides aminés
Licenciée en chimie
Mr Nicolas CLAESSENS
Tel: +32-(0)2-650.29.27
Fax: +32-(0)2-650.30.18
Email: nclaesse@ulb.ac.be
Doctorant
Sujet:
Synthèse et photoréactivité de complexes à topologie particulière avec le acides nucléiques
Assistant
Licencié en chimie
Melle Leslie HERMAN
Tel: +32-(0)2-650.29.27
Fax: +32-(0)2-650.30.18.
Email: lherman@ulb.ac.be
Doctorante
Sujet:
Photophysique de complexes du Ru(II) à ligand plan étendu
Licenciée en chimie
Mr. Désiré LAZA 
Tel: +32-(0)2-243.46.20
Fax: +32-(0)2-241.61.05
Email: Desire.Laza@just.gov.be
Doctorant
Sujet:
Analyse de résidus de tir par HPLC/MSMS
Bioingénieur

Thèmes de recherches:

Equipement:

Collaborations

Publications:

 
 Characterisation of bifunctional ruthenium(II) complexes, potential DNA photo-probes.
Presence of folded and unfolded conformers.
A. Del Guerzo, A. Kirsch-De Mesmaeker, M. Demeunynck, J. Lhomme
J. Chem. Soc., Dalton Trans., 1173-1179 (2000)

 
STM Imaging of a Heptanuclear Ruthenium(II) Dendrimer, Mono-Add Layer on Graphite
L. Latterini, G. Pourtois, C. Moucheron, R. Lazzaroni, J.-L. Brédas , Kirsch-De Mesmaeker,
F.C. De Schryver.
Chem. Eur. J., 6, 1331-1336 (2000)

 
Generation of Singlet Molecular Oxygen from H202 with Molybdate-exchanged Layered
Double hydroxides: Effects of Catalyst Composition and Reaction Conditions
F. van Laar, D.D. De Vos, F. Pierard, A. Kirsch-De Mesmaeker, L.Fiermans and P.A. Jacobs
Journal of Catalysis 197, 139-150 (2001)

 
Quantitative analysis of the effect of derivatisation of [Ru(BPY)2phen]2+ with a quinoline
moiety on the interaction with DNA
F.Piérard, A.Del Guerzo, A.Kirsch-De Mesmaeker, M.Demeunynck, J.Lhomme
Phys. Chem. Chem. Phys. 3, 2911-2920 (2001)

 
Stereoselective Interactions and Photo-Electron Transfers between Mononucleotides or
DNA and the Stereoisomers of a HAT-Bridged Dinuclear Ru(II) Complex
(HAT = 1,4,5,8,9,12-hexaazatriphenylene)
A. Brodkorb, A. Kirsch-De Mesmaeker, T.J. Rutherford and F.R. Keene
Eur. J. Inorg. Chem. 2151-2160 (2001)

 
Spectroscopic studies of structurally similar DNA-binding Ruthenium (II) complexes
containing the dipyridophenazine ligand
C. G. Coates, P. Callaghan, J. J. McGarvey, J. M. Kelly, L. Jacquet, A. Kirsch-De Mesmaeker
J. Mol. Struc. 598, 15-25 (2001)

 
Tetrapyrido [3,2-a:2’,3’-c :3’’,2’’-h:2’’’,3’’’-j] acridine (tpac) : a new extended polycyclic
bis-phenanthroline ligand
M. Demeunynck, C. Moucheron , A. Kirsch-De Mesmaeker
Tetrahedron Letters 43, 261-264, (2002).

 
Luminescence Quenching of Ru-Labeled Oligonucleotides by Targeted Complementary Strands
D. Garcia-Fresnadillo, N. Boutonnet, S. Schumm, C. Moucheron, A. Kirsch-De Mesmaeker,
E. Defrancq, J.F. Constant and J. Lhomme
Biophysical Journal, 82, 978-987 (2002)

 
Novel DNA Sensor for Guanine Content
A. Del Guerzo, A. Kirsch-De Mesmaeker
Inorg.Chem., 41, 938-945 (2002).

 
Influence of the Sequence Dependent Ionization Potentials of Guanines on the Luminescence
Quenching of Ru-Labeled Oligonucleotides : A Theoretical and Experimental Study
S. Schumm, M. Prévost, D. Garcia-Fresnadillo, O. Lentzen, C. Moucheron, and
A. Kirsch-De Mesmaeker
J. Phys. Chem. B, 106, 2763-2768 (2002)

 
In vitro inhibition of gene transcription by novel photo-activated polyazaaromatic ruthenium(II)
complexes
M. Pauly, I. Kayser, M. Schmitz, M. Dicato, A. Del Guerzo, I. Kolber, C.Moucheron and
A. Kirsch-De Mesmaeker
Chem. Comm., 1086-1087 (2002).

 
Picosecond studies of Ruthenium and Rhenium dipyridophenazine complexes in solution and
when bound to polynucleotides
J.M. Kelly, C.M. Creely, M.M. Feeney, S. Hudson, W.J. Blau, B. Elias,
A. Kirsch-De Mesmaeker, P. Matousek, M. Towrie, A.W. Parker
Lasers for Science Facility Programme-Chemistry, Annual Report 2001/2002, p.111-114.

 
Ultrafast Transient Absorption Studies of Ruthenium and Rhenium Dipyridophenazine Complexes
Bound to DNA and Polynucleotides
C.M. Creely, J.M. Kelly, M.M. Feeney, S. Hudson, J.C. Penedo, W.J. Blau, B. Elias,
A. Kirsch-De Mesmaeker, P. Matousek, M. Towrie,
A.W. Parker, J.S. Dyer, M.W. George, C.G. Coates and J.J. Mc Garvey
Proc. SPIE 4876, 92-102 (2002)

 
Photocrosslinking in Ruthenium-Labelled Duplex Oligonucleoties
O. Lentzen, J.-F. Constant, E. Defrancq, M. Prévost, S. Schumm, C. Moucheron, P. Dumy and
A. Kirsch-De Mesmaeker
ChemBioChem, 4, 195-202, (2003)

 
Comparison of the NMR enantiodifferentiation of a chiral Ruthenium(II) complex of C2 symmetry
using the TRISPHAT anion and a lanthanide shift reagent
G. Bruylants, C. Bresson, A. Boisdenghien, F. Piérard, A. Kirsch-De Mesmaeker, J. Lacour and
K. Bartik
New J. Chem. 27, 748-751 (2003)

 
Synthesis and characterization of optically active and racemic forms of cyclometalated Rh(III)
complexes. An experimental and theoretical emission study.
L. Ghisdavu, O. Lentzen, S. Schumm, A. Brodkorb, C. Moucheron and A. Kirsch-De Mesmaeker
Inorg. Chem., 42, 1935-1944 (2003)

 
Photoadduct leading to crosslinking in Ru(II) derivatized oligonucleotides.
O. Lentzen, J-F. Constant, E. Defrancq, C. Moucheron, P. Dumy, A. Kirsch-De Mesmaeker
Nucleosides, Nucleotides & Nucleic acids, 22, 5-8 (2003)

 
Synthesis of an oxyamino-containing phenanthroline derivative for the efficient preparation of
phenanthroline oligonucleotide oxime conjugates
S. Deroo, E. Defrancq, C. Moucheron, A. Kirsch-De Mesmaeker and P. Dumy
Tetrahedron Letters 44, 8379-8382 (2003)

 
Determination of DNA guanine sites forming photo-adducts with Ru(II)-labeled oligonucleotides;
DNA polymerase inhibition by the resulting photo-crosslinking
O. Lentzen, E. Defrancq, J-F. Constant, S. Schumm, D. Garcia-Fresnadillo, C. Moucheron,
P. Dumy et A. Kirsch-De Mesmaeker
J. Biol. Inorg. Chem. 9, 100-108 (2004).

 
Photophysical properties of Ruthenium(II) polyazaaromatic compounds: A Theoretical insight.
G. Pourtois, D. Beljonne, C. Moucheron, S. Schumm, A. Kirsch-De Mesmaeker, R. Lazzaroni
 and J-L. Brédas
J.Am.Chem.Soc. 126, 683-692 (2004).

 
[ Ru(TAP)2(dppz)]2+: A DNA intercalating complex, which luminesces strongly in water and
undergoes photo-induced proton-coupled electron transfer with guanosine-5'-monophosphate
I. Ortmans, B. Elias, J.M. Kelly, C. Moucheron and A. Kirsch-De Mesmaeker
J. Chem. Soc. Dalton trans. 668-676 (2004).

 
A mixed-bridging ligand nonanuclear Ru(II) dendrimer containing a trischelating core.
Synthesis and redox properties
J. Leveque, C. Moucheron, A. Kirsch-De Mesmaeker, F. Loiseau, S. Serroni, F. Puntoriero,
S. Campagna, H. Nierengarten and A. Van Dorsselaer
ChemComm. 878-879 (2004).

 
The diastereoisomeric forms of a mononuclear Ru(II) complex bearing a bis-phenanthroline
Tröger's base
C. Bresson, M. Lhumer, M. Demeunymck, A. Kirsch-De Mesmaeker and F. Piérard
Tetrahedron Letters 45, 2863-2866 (2004).

 
Photoadducts of metallic compounds with nucleic acids – role played by the photoelectron
transfer process and by the TAP and HAT ligands in the RuPicomplexes
R. Blasius, C. Moucheron and A. Kirsch-De Mesmaeker
Eur. J. Inorg. Chem., 3971-3979 (2004)

 
Adduct formation by photo-induced electron transfer between photo-oxidising Ru(II) complexes
and tryptophan
E. Gicquel, A. Boisdenghien, E. Defrancq, C. Moucheron and A. Kirsch-De Mesmaeker
J. Chem. Soc. ChemComm, 2764-2765 (2004).

   
Metallotherapeutic Drugs  & Metal-based Diadnostic Agents. The use of metals in medecine.
Chapitr 19: Perspectives of Ruthenium complexes in cancer therapy.
O. Lentzen , C. Moucheron and A. Kirsch-De Mesmaeker
Wiley, (2004) pages 359-378. Editors: M. Gielen and E. Tiekink.

 
Dendritic tetranuclear Ru(II) complexes based on the nonsymmetrical PHEHAT bridging ligand
and their building blocks: synthesis, characterization, and electrochemical and
photophysical properties
J. Leveque, B. Elias, C. Moucheron and A. Kirsch-De Mesmaeker
Inorganic Chemistry, vol. 44, 2, 393-400 (2005).

 
Photoreaction of [Ru(hat)2phen]2+ with guanosine-5'-monophosphate and DNA: formation
of new types of photoadducts
R. Blasius, H. Nierengarten, M. Lhumer, J-F. Constant, E. Defrancq, P. Dumy, A. van Dorsselaer,
C. Moucheron and A. Kirsch-De Mesmaeker.
Chem. Eur. J., 11, 1507-1517 (2005).

 
Detection of secondary structures in 17-mer Ru(II)-labeled single-stranded oligonucleotides
from luminescence lifetime studies.
D. Garcia-Fresnadillo, O. Lentzen, I. Ortmans, E. Defrancq and A. Kirsch-De Mesmaeker.
J. Chem. Com. Dalton Transactions, 852-856 (2005).

   

Ru(TAP)32+ photosensitized DNA cleavage studied by Atomic Force Microscopy and
electrophoresis: a comparative study.
H. Uji-i, P. Foubert, F. De Schryver, S. De Feyter, E. Gicquel, A. Etoc, C. Moucheron
  
and A. Kirsch-De Mesmaeker.
Chem. Eur. J. Com. WEB site: www.chemeurj.org
     
Ru(phen)2(PHEHAT)2+ and Ru(PHEN)2(HATPHE)2+: two Ru(II) complexes with the
same logands but different photophysics and spectroelectrochemistry.
A. Bousdenghein, C. Moucheron and A. Kirsch-De Mesmaeker.
Inorg. Chem. 44  7678-7685 (2005).

   

 

Liens intéressants:

Réalisation Erik & Robert Vandeloise, Email: Robert.Vandeloise@ulb.ac.be
Dernière modification, 31/08/2007