ARC 2016-2021

Consolidator 2016

Designing supramolecular interactions using reactive complexes

A big challenge in Material Science is to unravel general schemes for the rational design of ’smart’ functional materials, whose optical, electronic or molecular properties, among others, can be tailored to respond to specific external stimuli, more...

Spokesperson: MOGNETTI Bortolo Matteo, Service de Physique des Systèmes complexes et Mécanique statistique



DYNAMIC FUNCTIONAL DATA

Since storing data electronically is steadily becoming easier and cheaper, one is nowadays often collecting nearly continuous data records. Examples can be found in diverse fields, including environmental sciences, more...

Spokesperson: HÖRMANN Siegfried, Département de Mathématique



The Entropy Compression Method

Many computational problems of interest are difficult, in the sense that no efficient (polynomial time) algorithm solving them is known. This is for instance the case for the traveling salesman problem, who has to find a shortest circuit visiting a given set of cities: no fast algorithm has been found for this apparently simple problem when the number of cities is large, more...

Spokesperson: JORET Gwenaël, Département d’Informatique



Characterization of esophagus cancer initiation and development

Esophageal carcinomas (EsC) is currently the eighth most frequent cancer in the world, with approximately 450,000 new cancer cases annually worldwide. Due to its aggressive nature, this cancer is associated to a poor survival rate: only 5%-15% at five years. Barrett’s syndrome is considered as a precancerous lesion , more...

Spokesperson: BECK Benjamin, IRIBHM, U-CRC



Comprehensive Assessment of Diet in Adolescents and Young Adults in Belgium: Social and Cultural Disparities

Katia Castetbon and researchers from The School of Public Health propose to develop an ambitious research program aiming at evaluating, over time, public health initiatives regarding diet in relation to social inequalities. The first step will consist, more...

Spokesperson: CASTETBON Katia, Ecole de Santé publique



Does sex restrain genome evolution? An experimental investigation using yeast as a model organism

In sexual animals, chromosomes are organised in pairs, allowing allelic recombination during meiosis. During a previous international collaboration, Jean-François Flot and his colleagues sequenced and analysed the genome of the asexual rotifer Adineta vaga, a microscopic species, more...

Spokesperson: FLOT Jean-François, Evolution biologique et Ecologie



Molecular mechanisms of bacterial persistence

The spread of resistant bacteria is a major public health threat. Virtually all bacteria can produce phenotypic variants of actively dividing cells, known as "persisters", that are tolerant to most known antibiotic. The formation, more...

Spokesperson: GARCIA-PINO Abel, Laboratoire de Biologie Structurale et Biophysique



Descriptions of rituals in Italy in the first millennium BC

A number of languages were spoken in Italy in the first millennium BC. With the exception of Latin and Greek, these languages are fragmentarily attested, mainly through quite short inscriptions. But even so, detailed descriptions of the ritual practices of that time are to be found therein, more...

Spokesperson: DUPRAZ Emmanuel, Philixte (Études littéraires, philologiques et textuelles)



Between the devil and the deep blue sea. Implementing language policy in urban heteroglossic schools

DMany urban schools today welcome pupils from different linguistic origins who must nevertheless adapt to a monolingual school policy implemented by their teachers. Sociolinguistic research has up to this point been much more engaged in, more...

Spokesperson: JASPERS Jürgen, Centre de recherche en linguistique LaDisco



Advanced 2016

Searches for a dark matter emitted neutrino signal

Dark matter (DM) is five times more abundant than ordinary matter in the Universe, but what it is made of remains obscure. The main question which is still open is : what is the nature of DM as particles? In 2013 the IceCube experiment, more...

Spokesperson: Thomas Hambye, Physique théorique.



Self-Organising circuits For Interconnected, Secure and Template computing (SOFIST)

Over the last 50 years, the CMOS technology allowed more and more efficient manufacturing of integrated circuits. This technology has now reached not only the physical limits, but also important economic barriers! Even if we are ready to produce integrated circuits with minimum features size below 10 nanometers, more...

Spokesperson: Dragomir Milojevic, BEAMS.



Non-Zero Sum Game Graphs: Applications to Reactive Synthesis and Beyond

Reactive systems are computer systems that maintain a continuous interaction with the environment in which they operate. Such systems are nowadays part of our daily life: think about common yet critical applications like engine control units in automotive, plane autopilots, medical devices, more...

Spokesperson Jean-François Raskin, Méthodes formelles et vérification.



Understanding the contribution of AU-rich element (ARE)-mediated mRNA decay to the maintenance of skin and gut immune homeostasis

Epithelial barriers such as gut and skin are continuously exposed to environmental stimuli, including commensal and pathogenic microbes. It is essential for the host to control inflammatory processes in order to prevent infections and also avoid development of inflammatory diseases such as psoriasis, more...

Spokesperson: Stanislas Goriely, Institut d'immunologie médicale.



APOL1 - SRA interplay

For many years, the Molecular Parasitology Laboratory has been mainly devoted to the study of the mechanisms of adaptation of African trypanosomes, parasites that cause sleeping sickness in man and the nagana disease in cattle. Previous lab studies have shown that, more...

Spokesperson: David-Pérez-Morga, Laboratoire de Parasitologie Moléculaire.



Studies of transcriptional mechanisms regulating HIV-1 post-integration latency: implications for innovative therapeutic strategies

Antiretroviral multitherapy increases survival and quality of life of HIV-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication, since HIV persists in viral latent reservoirs. Indeed, this small population of HIV-1 latently-infected cellular reservoirs, more...

Spokesperson: Carine Van Lint, Laboratoire de Virologie moléculaire.



East Asian Youth: Identities and Practices in Public Spaces (GENEsYs)

East Asian societies have, over the past few decades, undergone dramatic demographic, economic, political and technological transitions. Particularly impacted by these transformations is the younger generation, which experiences differ greatly from earlier generations. Continually exposed, more...

Spokesperson: Vanessa Frangville, Langue et littérature chinoises.



Locals dealing with Developmental Incomes: an updated approach combining Anthropology of Economics and Social Economy (West & Central Africa)

This research proposal focuses on Development Incomes (DI), namely on financial amounts drawn from the exploitation of natural resources and allocated to riverine communities with a view to invest in sustainable development. The major objective is to assess assess social and economic impacts, more...

Spokesperson: Véronique Joiris, Centre d'Anthropologie Culturelle.



Why Lefort Matters : A Conceptual Genealogy of Contemporary Normative Issues

Claude Lefort (1924-2010) may be seen today as one of the leading political theorists of the late twentieth century. Yet the secondary literature on his output remains peculiarly sparse, especially outside the French-speaking world. This research project sets out to bridge this gap using, more...

Spokesperson: Justine Lacroix, Centre de théorie politique



ARC 2014-2019

Consolidator 2014

Photoinduced Copper-Catalyzed Reactions: New Directions in Copper Catalysis - a Unified Approach to Highly Valuable Building Blocks

Whether we're talking about developing polymers, new materials or producing drugs, all these scientific fields need to synthesise organic molecules , more...


Spokesperson: Gwilherm Evano, Service de Chimie et PhysicoChimie Organiques



Theoretical Foundations of Data Transformations

Formal methods are mathematical models and tools to reason about computer systems. Based on the deeply studied theories of automata and logics , more...


Spokesperson: Emmanuel Filiot, Département d'Informatique



PREDICT - PREDIctive numerical simulation of novel Combustion Technologies through validation and uncertainty quantification

Flameless combustion represents a very attractive solution for combustion systems as it can provide high combustion efficiency with low pollutant emissions , more...


Spokesperson: Alessandro Parente, Service d'Aéro-Thermo-Mécanique



PIONEER - Physico-chemistry in out-of-equilibrium nonideal environments and spatially extended reactive systems

The objective of this project is to develop a theoretical framework for out-of-equilibrium nonideal systems , more...


Spokesperson: Laurence Rongy, Non Linear Physical Chemistry Unit



Hopf algebras and the Symmetries of Non-commutative Spaces

As a classical group describes the symmetries of the space upon which it acts, a Hopf algebra can be understood as the algebraic object that , more...


Spokesperson: Joost Vercruysse, Département de Mathématique, Service Algèbre et Combinatoire



Unveiling novel mechanisms of bêta cell dysfunction and death in diabetes

Diabetes is caused by loss of pancreatic bêta cell functional mass. The molecular mechanisms leading to , more...


Spokesperson: Miriam Cnop, Laboratory of Experimental Medicine - ULB Center for Diabetes Research



Characterization of the temporal dynamics and the electrophysiological bases of resting state network

At rest (in the absence of task), the activity of the human brain is not stochastic but spatially and temporally organized in resting state networks , more...


Spokesperson: Xavier De Tiège, Laboratoire de Cartographie fonctionnelle du Cerveau, UNI - ULB Neuroscience Institute



Genetic control of brain vascular development

Despite the importance of the neurovascular unit in a large set of central nervous system disorders, the mechanisms underlying brain angiogenesis and brain endothelial specialization are unclear , more...


Spokesperson: Benoit Vanhollebeke, Laboratoire de Parasitologie moléculaire



Understanding the Rising Middle Class in Sub-Saharan Africa Symbolic boundaries, State and Social Groups in Liberia

Over the last decade economic growth in the African continent has been particularly high and the middle class is increasing , more...


Spokesperson: Mathieu Hilgers, Laboratoire d'Anthropologie des Mondes Contemporains



Context in autism

The widespread view is that persons with Autism Spectrum Disorders (ASD) suffer from a global pragmatic impairment , more...


Spokesperson: Mikhail Kissine, LaDisco



What shall I do? Transformations of practical reason in early modern philosophy prior to Kant

This project aims to challenge the prevailing view about early modern Ethics. To put it briefly , more...


Spokesperson: Arnaud Pelletier, Département de Philosophie



Advanced 2014

Models for Quantum Black Holes and Cosmologies

Understanding the quantum properties of black holes and cosmological spacetimes is one of the most profound problems , more...


Spokesperson: Frank Ferrari, Service de Physique Théorique et Mathématique



Design of high density protein microarrays for ligand binding detection by FTIR imaging

Proteins are not only involved in a very large number of biological processes but are also more and more widely used in , more...


Spokesperson: Erik Goormaghtigh, Structure et Fonctions des Membranes Biologiques



Structured statistical and computational tools in high-dimensional recovery, with applications in medical imaging

The researchers plan to develop information criteria for sparse, structured selection and estimation of high-dimensional, linear models , more...


Spokesperson: Ignace Loris, Mécanique et mathématique appliquée



Deciphering oligo- to polygenic genetic architecture in brain developmental disorders

Even when a single causative gene mutation is involved, a few (oligogenic) to many (polygenic) additional genetic variants contribute to disease outcome , more...


Spokesperson: Marc Abramowicz, Dept of Genetics, Hôpital Erasme et Laboratory of Medical Genetics, IRIBHM



The nucleolus in Health and Disease

Ribosomes and nuclear pore complexes (NPCs) are essential cellular nanomachines responsible for protein synthesis and nucleocytoplasmic trafficking , more...


Spokesperson: Denis Lafontaine, RNA Molecular Biology



From human pluripotent stem cells to cortical circuits

The development of connectivity in the cerebral cortex has major implications for our understanding of brain function and disease , more...


Spokesperson: Pierre Vanderhaeghen, IRIBHM, UNI



Governing values, governing through values, governed by values? The European Union as a risk polity

Values at the core of European integration have been widely discussed in recent years due to several major evolutions in EU governance , more...


Spokesperson: François Foret, Cevipol, IEE



Strategic Litigation: using courts to achieve social change? Fighting poverty and impunity in judicial arenas

This project will explore the transnational circulation of the practice of strategic litigation (SL). In the human rights field, , more...


Spokesperson: Annemie Schaus, centre de droit public



A Belgian Peculiarity? Sexual Revolution and (De)pilarisation from 1960 to 2000. A contribution to the History of the Transformation of Gender and Sexuality Norms

Pilarisation, which refers to the management of religious and philosophical diversity in highly divided societies, is one of the fundamental features of Belgian society , more...


Spokesperson: Cécile Vanderpelen, CIERL



ARC 2012-2017

Optical Reservoir Computing, and Applications to High Speed Telecommunications

This project lies at the interface of reservoir computing, onlinear optical dynamical systems, and high speed wireless communication. Reservoir computing is an emerging bio-inspired computation technique that is both powerful and flexible, in which the computation is performed by the internal dynamics of a complex nonlinear system , more...

Spokesperson: Serge Massar


Convective instabilities in porous media and sea ice (CONVINCE)

Global warming is nowadays clearly recognized to be related to increased concentrations of greenhouse gases in the atmosphere. Sequestration in geological subsurface zones like saline aquifers for instance or sink in sea ice and further in the deeper ocean of such gases are two key processes that can help to respectively reduce these concentrations and refine our prognostic scenarios, , more...

Spokesperson: Anne De Wit


COmputational, PHYsical and MAthematical approaches to complexity (COPHYMA)

The notion of complexity was originally defined as a mathematical concept, regardless of its practical relevance. With the advent of computers, it soon became a fundamental notion in order to measure the resources , more...

Spokesperson: Nicolas Cerf


Nutrition and circadian rhythms in plants

The world must grow more crops on its currently arable land to meet increasing demand for food in the face of climate change and the need for long-term sustainability. Breeding crops with a better use efficiency of fertilizers and biomass production, , more...

Spokesperson: Jean-Christophe Leloup


Interplay between Analysis, Probability and Actuarial Sciences (IAPAS)

The aim of this project is to develop new mathematical methodologies for solving substantial and modern issues located at the interface between probability theory, functional and complex analysis and insurance mathematics, , more...

Spokesperson: Pierre Patie


Delineation of molecular and cellular mechanisms regulating the coordinated development of the thyroid gland and the cardiovascular system

One in every 3000 newborns presents a deficit in thyroid hormone production (congenital hypothyroidism, CH) that if it isn't treated, will lead to irreversible cognitive defects. Around 85% of CH cases result from developmental defects during embryogenesis, , more...

Spokesperson: Sabine Costagliola


Patho-physiological role, structural analysis and drug targeting of ammonium/ammonia transport proteins of the conserved Mep-Amt-Rhesus factors family

The ammonium ion is a ubiquitous molecule, used as principal source of nitrogen by microbes and plants. This ion is however a cytotoxic metabolite occupying a central position in the control of acid-base homeostasis in animals, , more...

Spokesperson: Anna Maria Marini


Role of inflammation and tumor microenvironment in epithelial cancer

The role of chronic inflammation as a contributing factor in the development of cancer is well established. Various leukocyte populations can either contribute to their elimination of tumor cells or contribute to their survival. Tumor progression involved the expression of chemokines and other factors that attract leukocytes, , more...

Spokesperson: Marc Parmentier, Jean-Yves Springael


PRotein dEtection for in vivo DIagnosis using CaTheterlc Optical fibre bioseNsors

Optical fiber biosensors can perform sensitive and quantitative measurements of the presence and concentration of biomolecules such as proteins or DNA. They can therefore contribute to major advances in medical diagnosis, food quality control, drug development and environmental monitoring , more...

Spokesperson: Nicolas Cauche


NAD metabolism and the control of innate immune responses

In addition to its well-known role in energy metabolism, the nicotinamide adeline dinucleotide (NAD) has been recently shown to play an important role in the regulation of a vast array of cellular responses. The involvement of NAD in these regulatory processes , more...

Spokesperson: Véronique Kruys


Culture, mobility, territory: the emergence and transformation of a metropolitan identity in Brussels (18th-21st centuries)

This project aims to investigate the metropolitan identity that emerged from the combined effects of culture and mobility. The researchers will focus their attention on the complementary aspects of these two vast fields , , more...

Porte-parole: Laurence Brogniez


Under the banner of merit and cultural conformity. The new integration and immigration policy in Europe

This project sets out to analyse the causes and effects of new integration policy in Europe since the beginning of the new millennium which saw the coexistence of two contradictory movements , more...

Porte-parole: Andrea Rea


Globalisation, sociocultural recomposition and political demands in the Muslim world

With a population of almost 1.5bn people sharing a common religion, the Muslim world today is made up of a group of very different States with greatly varied political regimes, economic development, and sets of problems, , suite...

Porte-parole: Firouzeh Nahavandi

ARC 2010-2015

Beyond Einstein: fundamental aspects of gravitational interactions

L'interaction gravitationnelle, bien que la plus visible des forces fondamentales connues à ce jour, reste très mal comprise. Dans la recherche d'une théorie unifiée des interactions fondamentales, le but du projet consiste à comparer la relativité générale d'Einstein à des approches alternatives, , suite...


Complex, Sympletic and contact geometry, quantization and interactions

La géométrie symplectique est une interface entre la géométrie et la physique. La structure symplectique est également le point de départ pour la quantification du système. Le passage conceptuel de la géométrie au système classique et ensuite au système quantique est compliqué, , suite...


Enjeux individuels et collectifs liés à la dispersion et à l'agrégation: causes proximales et conséquences ultimes à différentes échelles

Les stratégies d'occupation de l'espace des organismes associent la dispersion à grande échelle et des agrégations-coopérations à petite échelle. La synergie entre ces deux processus permet l'exploration, l'exploitation de nouvelles ressources ainsi que la réduction de la prédation ou des stress environnementaux, , suite...


Formation de phases en "film mince" par des semiconducteurs cristaux liquides: compréhension fondamentale des processus physiques et chimiques

L'objectif principal du projet "Formation de phases en "film mince" par des semiconducteurs critaux liquides: compréhension fondamentale des processus physiques et chimiques" est d'atteindre une compréhension fondamentale des paramètres chimiques et physiques conduisant à la formation de phases en film mince, , suite...


Small scale plasticity with confinement and interfacial effects: a combined experimental-computational approach

Dans de nombreux matériaux modernes, les mécanismes de déformation plastique se trouvent confinés sur des longueurs submicroniques. C'est le cas des M(N)EMS (Micro(Nano) Electro Mechanical System) ou des couches minces, , suite...


Theoretical and experimental approaches to surface reactions: from molecular dynamics to chiral induction

Les surfaces de certains métaux peuvent servir à convertir des réactifs en produits grâce au phénomène bien connu qu'est la catalyse. Comprendre les processus de la catalyse au niveau des surfaces à l'échelle de la molécule contribue à résoudre certains problèmes majeurs de société comme la pollution atmosphérique ou la production de matières respectueuses de l'environnement, , suite...


Structural, biochemical and physiological analysis of amino acid transporters and sensors

Les protéines de transport membranaire existent dans toutes les cellules vivantes et leur dysfonctionnement est à l'origine de plusieurs pathologies chez l'homme, suite...


Discovery of the molecular pathways regulating pancreatic beta cell dysfunction and apoptosis in diabetes using functional genomics and bioinformatics

Les deux formes majeures de diabète (diabètes de type 1 et de type 2 - DT1 et DT2) affectent 30 millions d'individus en Europe, diminuant leur espérance et leur qualité de vie. La prévalence de ces deux types de diabète est en constante augmentation et pourrait doubler au cours de la prochaine décennie, , suite...


Genomic, transcriptomic and epigenomic analysis of breast cancer: a step towards the individualization of breast cancer treatment

Le cancer du sein est le cancer le plus fréquent chez la femme. De manière générale, les facteurs pronostiques et les facteurs prédictifs de réponse actuellement utilisés en routine sont incomplets et insuffisants pour expliquer les différences de survie ou de réponse observées en clinique, , suite...


Pathophysiology of brain plasticity processes in memory consolidation

La consolidation mnésique fait référence à l'ensemble des processus complexes de plasticité cérébrale, survenant au cours du temps et notamment du sommeil, qui permettent à des apprentissages nouvellement acquis d'être intégrés à long terme dans les réseaux neuronaux, avec pour résultat d'enrichir et diversifier le répertoire comportemental, , suite...


Standardizing differences. Classification and norm-setting as instruments in 20th-century medical practices

La collaboration projetée, au carrefour des cultures des sciences médicales et des sciences humaines, a pour objet d'initier un programme d'activité centré sur l'étude des mécanismes de classification utilisés par la pratique médicale dans l'histoire du 20ème siècle, en général, et dans le cas de la psychiatrie en particulier, suite...


High-dimensional data in Economics and Finance

Le projet "High-dimensional data in Economics and Finance" a pour sujet l'exploitation de larges ensembles de données en macroéconomie et en finance et s'articule autour de trois thèmes principaux, suite...


Mobilisations professionnelles et engagements personnels dans le travail contemporain: les nouvelles tensions des espaces de qualification

Les évolutions sociales contemporaines attribuent une place prépondérante à la symbolique de la mobilité continue, dans des champs comme celui du travail, de l'orientation et de l'activation professionnelle, de l'aide sociale, de l'enseignement, de l'attractivité territoriale, descriptif


Le juge: un acteur en mutation

L'ordre juridique continental accorde peu de place à l'action du juge, officiellement limitée au rappel de la norme. Le pouvoir propre du juge n'y a donc pas de statut politique. Mais ce mythe d'un juge passif, "bouche de la loi", est ébranlé par le phénomène de "montée en puissance du juge" qui, s'il est contesté dans sa radicalité ou sa nouveauté, impose de considérer le juge dans différents domaines du droit comme un véritable acteur, , suite...


Statistical methods for complex static and dynamic dependence models

Dans presque tous les domaines d'applications, les statisticiens sont confrontés à des données de plus en plus complexes, ce qui s'explique autant par les progrès importants que connaissent les appareils de mesure que par l'amélioration constante des dispositifs de stockage, suite...