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Laboratoire de signalisation neurovasculaire [Laboratory of Neurovascular Signaling]
Faculté des Sciences / faculty of Sciences - Biologie moléculaire (unité ULB131)

Biologie moléculaire et cellulaire des trypanosomes africains. Etude des contrôles de l'expression des gènes chez les trypanosomes. Mécanismes de la variation antigénique chez les trypanosomes. Etude des relations hôte-parasite dans la trypanosomiase. Recherche d'antigènes vaccinants contre les trypanosomiases. [Our goal is to understand how the vascular and neural systems dynamically communicate to orchestrate brain development and function. It is now clear that blood vessels are more than passive conduits for blood flow and that tissue-specific vascular beds not only match the metabolic demands of the perfused organs but also act as important signaling centers releasing angiocrine factors that govern tissue morphogenesis and function. Proper brain function relies on elaborate neurovascular communications that, when perturbed, often have disabling or fatal consequences. Hence, there is great interest in studying the mechanisms that shape the anatomy and control the functionality of the cerebrovasculature, not only to better understand how the brain develops and works, but also to elaborate innovative therapeutic strategies for neurological disorders. We leverage the zebrafish brain as a normoxic and transparent setting to explore CNS neurovascular interactions in real time and at single-cell resolution in order to better understand through which cellular and molecular mechanisms CNS vascular invasion and maturation are controlled by neural signals and, reciprocally, how the developing vascular system impacts brain patterning and function.In addition, our laboratory contains two independent research sub-units studying molecular parasitology and inflammation molecular biology. ]



coordonnées / contact details


Laboratoire de signalisation neurovasculaire [Laboratory of Neurovascular Signaling]
tel +32-2-650.97.61, fax +32-2-650.97.50, Benoit.Vanhollebeke@ulb.ac.be
http://nvasc.ulb.be/vanhollebekelab/
Campus de Charleroi - Gosselies (Biopark), IBMM, niveau 2, local AS.2.110
CP300, rue des Professeurs Jeener et Brachet 12, 6041 Charleroi (Gosselies)

Pour en savoir plus, consultez le site web de l'unité.



responsable / head


Benoit VANHOLLEBEKE


composition / members


Sophie BONNOT Naguissa BOSTAILLE Pauline CABOCHETTE Carlos CRUZ Paula CUHNA Jean DE CLERCQ Line DE GRANDE Nathalie DUMONT Elisabeth DUPONT Marie EUBELEN Frédéric FONTAINE Anne GAUQUIER Ali KASSEM Laurence LECORDIER Daniel MONTEYNE Etienne PAYS David PEREZ-MORGA Philippe POELVOORDE Leslie SANDERSON Maxime STEISEL Patricia TEBABI Luc VANHAMME Corentin VERMEIREN


projets / projects


Signalisation neurovasculaire [Neurovascular Signaling]
Signalisation neurovasculaire [Neurovascular signaling]

Parasitologie Moléculaire (cellule de recherche, D.Pérez-Morga) [Molecular Parasitology]
Caractérisation des facteurs immunosuppresseurs du trypanosome. Etude de l'induction et de la capture du TNF-alpha et de l'interféron-gamma par le trypanosome. Etude du rôle de ces cytokines dans la parasitémie. [Characterization of the immunosuppressive factors of the trypanosome. Study of the induction and the uptake of TNF-alpha and interferon-gamma by the trypanosome. Role of these cytokines in parasitaemia.]

Biologie moléculaire de l'inflammation (cellule de recherche, L.Vanhamme) [Molecular Biology of Inlammation]



publications





theses


Vanhollebeke, B., Département de Biologie Moléculaire, Laboratoire de Parasitologie Moléculaire, ULB, IBMM., 2008



prix / awards


Prix Albert Dubois (Académie de Médecine, Bruxelles), 2010. - Benoit VANHOLLEBEKE

MBL scholarship award. ''Zebrafish Development and Genetics'' (Woodshole, MA, USA), 2009. - Benoit VANHOLLEBEKE

HFSP long term fellowship Award, 2009. - Benoit VANHOLLEBEKE

EMBO long term fellowship Award, 2008. - Benoit VANHOLLEBEKE

Prix Frédéric et Cécile Lints, 2001. - Benoit VANHOLLEBEKE



savoir-faire/équipements / know-how, equipment


Microscope confocal

Editing génomique

Génétique du poisson-zèbre



mots clés pour non-spécialistes / keywords for non-specialists


angiogenèse barrière hémato-encéphalique interaction neurovasculaire poisson zèbre signalisation cellulaire


disciplines et mots clés / disciplines and keywords


Accompagnement des mourants Biologie Biologie moléculaire Microbiologie et protistologie [parasitologie hum. et anim.] Parasitologie

angiogenèse barrière hémato-encéphalique poisson-zèbre trypanosome africain