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Anion transport across lipid membranes by supramolecular receptors [Anion transport across lipid membranes by supramolecular receptors]

Channel-forming membrane proteins are responsible for the transport of charged species through cell membranes. Dysfunction in ion transport is the cause of numerous diseases, of which cystic fibrosis is probably the most well-known. It is possible to compensate for the defect or under-expressed membrane protein channel activity by using synthetic molecules which can carry anions through the lipid bilayer. Our goal is to study the thermodynamics, kinetics, and structural parameters of anion carriers inside lipid bilayer membranes in order to highlight the key parameters governing the efficiency of organic receptors as transporters. We use both state-of-the-art physical organic chemistry and biophysical methods, such as advanced NMR techniques, microcalorimetry and fluorescence spectroscopy, to obtain an extensive understanding of the transport phenomenon and propose new rules for the design of the next generation of anion transporters. [Channel-forming membrane proteins are responsible for the transport of charged species through cell membranes. Dysfunction in ion transport is the cause of numerous diseases, of which cystic fibrosis is probably the most well-known. It is possible to compensate for the defect or under-expressed membrane protein channel activity by using synthetic molecules which can carry anions through the lipid bilayer. Our goal is to study the thermodynamics, kinetics, and structural parameters of anion carriers inside lipid bilayer membranes in order to highlight the key parameters governing the efficiency of organic receptors as transporters. We use both state-of-the-art physical organic chemistry and biophysical methods, such as advanced NMR techniques, microcalorimetry and fluorescence spectroscopy, to obtain an extensive understanding of the transport phenomenon and propose new rules for the design of the next generation of anion transporters.]



équipe


Elisabeth VALKENIER-VAN DIJK


disciplines et mots clés déclarés


Biochimie

anion recognition supramolecular chemistry transmembrane transport