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William DENIS


coordonnées


William DENIS
tel +32-2-650.20.48, william.denis@ulb.ac.be
Campus du Solbosch
CP*, avenue F.D. Roosevelt 50, 1050 Bruxelles



unités de recherche


Ingénierie des Nanosystèmes Moléculaires [Engineering of Molecular Nanosystems] (EMNS)



projets


Solubilisation de récepteurs moléculaires hydrophobes par leur incorporation dans des micelles [Micellar solubilisation of hydrophobic molecular receptors]
The EMNS laboratory is interested in the development of supramolecular systems that can act as hosts in molecular recognition processes in water and accommodate guest molecules. Micellar solubilisation is a powerful method for dissolving hydrophobic molecules in aqueous environments. Micelles are for example widely used in pharmaceutical biotechnology for drug delivery and in extraction processes, avoiding in this manner the use of large amounts of organic solvents. The solubilisation of organo-soluble receptors in micelles is an interesting strategy to obtain water compatible nanosized supramolecular recognition devices which can be prepared via a straightforward self-assembly process. We have for example reported results on the use of this strategy with salophen-based receptors. The micelles not only solubilize the metal complexes but also render the binding of anions more efficient in water than in a protic organic solvent such as methanol. [The EMNS laboratory is interested in the development of supramolecular systems that can act as hosts in molecular recognition processes in water and accommodate guest molecules. Micellar solubilisation is a powerful method for dissolving hydrophobic molecules in aqueous environments. Micelles are for example widely used in pharmaceutical biotechnology for drug delivery and in extraction processes, avoiding in this manner the use of large amounts of organic solvents. The solubilisation of organo-soluble receptors in micelles is an interesting strategy to obtain water compatible nanosized supramolecular recognition devices which can be prepared via a straightforward self-assembly process. We have for example reported results on the use of this strategy with salophen-based receptors. The micelles not only solubilize the metal complexes but also render the binding of anions more efficient in water than in a protic organic solvent such as methanol. ]



disciplines et mots clés déclarés


Chimie macromoléculaire Chimie organique

micelles recepteurs moléculaires