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Pierre LAMBERT


coordonnées


Ecole polytechnique de Bruxelles
Pierre LAMBERT
tel 02 650 42 44, fax 02 650 47 24, Pierre.Lambert@ulb.ac.be
Campus du Solbosch
CP165/14, avenue F.D. Roosevelt 50, 1050 Bruxelles




unités de recherche


Biomécanique et instrumentation [Biomechanic and Instrumentation] (BEAMS Biomed)
Microtechniques [Micro- and Biomechanical Engineering] (BEAMS-µTech-Biomech)



projets


EndoGES - Electrostimulateur gastrique implanté par endoscopie [EndoGES - Gastric electrical stimulator designed to be endoscopically implanted]
L'électrostimulation gastrique (GES) est une discipline récente provenant des recherches en stimulation cardiaque. L'idée de la GES est d'altérer l'activité myoélectrique naturelle de l'estomac dans le but de restaurer ou de perturber son fonctionnement normal. La GES a déjà montré son potentiel thérapeutique dans deux maladies digestives - la gastroparésie et l'obésité morbide - et elle semble prometteuse pour traiter des maladies supplémentaires comme le reflux gastrique oesophagien.Bien que moins invasives que leurs contreparties chirurgicales comme le bypass dans le cas de l'obésité, les techniques de GES doivent encore être améliorées pour pouvoir réellement percer. Premièrement, les stimulateurs devraient être améliorés et adaptés aux courants et formes d'onde à appliquer à l'estomac. A cet effet, plusieurs topologies de sources de courant sont examinées dans le service, et plus spécialement les topologies sans capacité de bloquage, lesquelles permettent un niveau de miniaturisation adéquat.Deuxièmement, les stimulateurs devraient être implantés par voie endoluminale, pour réduire encore l'invasivité des procédures qui requièrent encore à l'heure actuelle la création d'une poche sous-cutanée. Cette nouvelle méthode demande une miniaturisation encore plus grande, mais aussi un packaging adéquat pour l'implant, lequel pourrait être attaché durablement à la paroi de l'estomac et résister à son environnement très acide. Notre service couvre également cet aspect. [Gastric electrical stimulation (GES) is a recent research field that has derived from cardiac pacing. The idea behind GES is to alter the natural myoelectrical activity of the stomach in order to either restore or disturb normal parameters. GES has already demonstrated therapeutic effects in two severe digestive conditions - gastroparesis and morbid obesity - and is promising to treat additional conditions (e.g., GERD).Although already less invasive than their chirurgical counterparts like the Roux-en-Y gastric bypass to treat morbid obesity, the GES procedures need to be improved to really break through. First, the stimulators themselves should be enhanced and adapted to the stomach currents and stimulation patterns. In that regard, several current delivery topologies are under investigation in our labs, especially the 'dc blocking capacitor free' that enable the sufficient level of miniaturization.Second, the stimulator should be implanted endoscopically, to further reduce the invasiveness of the procedure that currently implies placement of the stimulator in a subcutaneous pocket. This new method implies further miniaturization as well as a special packaging that can be safely attached to the stomach wall and that could resist its harsh environment. This research covers this aspect as well, as we are currently testing some new patent pending concepts.]

NEOFOR
Création d'une plate-forme technologique pour la délivrance pulmonaire avancée d'agents pharmacologiques [Technological platform for advanced pulmonary delivery of Active Pharmaceutical Ingredients]

IAP 7/38 MicroMAST, Micromanipulation and Microfluidics: Multiscale Applications of Surface Tension [IAP 7/38 MicroMAST, Micromanipulation and Microfluidics: Multiscale Applications of Surface Tension]
The scientific objectives of this network are driven by fundamental questions raised in microfluidics, interfacial science, and micromanipulation. The rational use of surface tension, surface stress and capillary effects in micromanipulation will be applied to a selected number of highly relevant case studies by the network partners, including capillary gripping, capillary filling, capillary alignment, capillary sealing, capillary self-assembly and droplet manipulation. These fundamental questions can be grouped into three categories: 1. Fluid statics and dynamics: How much force is applied on solids by menisci and micro-flows in a given geometry? What happens if the solid bends when subject to these forces? Are the interfaces stable and what if not? What is the effect of an electric field? How can the microscopic description of wetting be translated into an adequate boundary condition at the macroscopic level? 2. Surface engineering: How does a contact line move on a rough surface? Can one pattern the surface microscopically to control this motion? How is the motion affected by evaporation, or by the presence of colloid particles in the liquid or at the interface? Do these particles interact with the micro-patterns on the surface? Can one create highly 3D patterns on the surface by using capillary forces? 3. Liquid engineering: How to measure the interfacial properties of complex liquids where apart from surface tension a surface viscoelastic response is present? How to infer macroscopic properties from the dynamics at the molecular scale? And how to engineer liquids and tailor them to the requirements arising from applications? Can one make a liquid that is biocompatible, and has a large surface tension and a low viscosity? The proposed program is highly multidisciplinary, as it combines the forefront research in physics, material science, chemistry and engineering. It will cover topics that range from fundamental theory with atomistic simulations to experiments to investigate the fundamentals and selected more applied case studies. It will address both static and dynamic points of view, and establish the link between the microscopic properties of liquids and surfaces, and the macroscopic performances expected in the case studies. To that aim, this IAP project has gathered a multi-disciplinary research team that covers all the disciplines listed above. The originality of this network relies in the efforts to enhance the collaboration of both the interfacial science, microfluidics and microengineering communities. [The scientific objectives of this network are driven by fundamental questions raised in microfluidics, interfacial science, and micromanipulation. The rational use of surface tension, surface stress and capillary effects in micromanipulation will be applied to a selected number of highly relevant case studies by the network partners, including capillary gripping, capillary filling, capillary alignment, capillary sealing, capillary self-assembly and droplet manipulation. These fundamental questions can be grouped into three categories: 1. Fluid statics and dynamics: How much force is applied on solids by menisci and micro-flows in a given geometry? What happens if the solid bends when subject to these forces? Are the interfaces stable and what if not? What is the effect of an electric field? How can the microscopic description of wetting be translated into an adequate boundary condition at the macroscopic level? 2. Surface engineering: How does a contact line move on a rough surface? Can one pattern the surface microscopically to control this motion? How is the motion affected by evaporation, or by the presence of colloid particles in the liquid or at the interface? Do these particles interact with the micro-patterns on the surface? Can one create highly 3D patterns on the surface by using capillary forces? 3. Liquid engineering: How to measure the interfacial properties of complex liquids where apart from surface tension a surface viscoelastic response is present? How to infer macroscopic properties from the dynamics at the molecular scale? And how to engineer liquids and tailor them to the requirements arising from applications? Can one make a liquid that is biocompatible, and has a large surface tension and a low viscosity? The proposed program is highly multidisciplinary, as it combines the forefront research in physics, material science, chemistry and engineering. It will cover topics that range from fundamental theory with atomistic simulations to experiments to investigate the fundamentals and selected more applied case studies. It will address both static and dynamic points of view, and establish the link between the microscopic properties of liquids and surfaces, and the macroscopic performances expected in the case studies. To that aim, this IAP project has gathered a multi-disciplinary research team that covers all the disciplines listed above. The originality of this network relies in the efforts to enhance the collaboration of both the interfacial science, microfluidics and microengineering communities.]

Stratégies d'isolation active [Active Vibration Isolation]
L'objectif de ce projet est de développer des nouvelles stratégies permettant d'isoler activement les futurs instruments dédiés à la physique expérimentale (tels que les collisionneurs de particules et les grands détecteurs d'ondes gravitationnelles) des perturbations environnementales. [The objective of this project is to develop active vibration isolation strategies to stabilize large future instruments dedicated to experimental physics, like particle collider, gravitational wave detectors. ]

Mini Micro Nano Project [Mini Micro Nano Project]
A new field of interest is the use of metallic materials in MEMS applications because of their interesting mechanical and wear properties. The objective of the Mini Micro Nano Project is to create a center of excellence in the field of micromechanical engineering with the cooperation of three ULB partners: the CAD-CAM, the Structural and Material Computational Mechanics and the Industrial Chemistry departments.The nanoscale world obeys to different rules than the macroscopic one. Due to the extreme down-scaling many practical problems are encountered in microhandling of small parts. These problems must be studied and solved in order to be able to design and produce reliable micromechanical tools. The CAD-CAM department is in charge of the development of a tool for surface interactions to be able to take into account the surface forces (that are of the outmost importance at nanoscale) for manipulator design and for the development of handling strategies.At small scales the behavior of materials changes significantly with respect to the bulk material at macro-scale, which leaves many unanswered questions. The Structural and Material Computational Mechanics Department is responsible for modeling the mechanical response of materials at nanoscale using appropriate theories to pass from the bulk material parameters to the nanoscale behavior.The previous tasks need inputs from special experiments. The practical research results must also be validated later on. The Industrial Chemistry Department brings its expertise in experimental characterization of materials and performs thorough chemical and physical characterization of materials and surfaces.The project will span five years, with the participation of three PhD students attached to the fore-mentioned three departments during four years and one post-doctoral fellow for the last two years. [A new field of interest is the use of metallic materials in MEMS applications because of their interesting mechanical and wear properties. The objective of the Mini Micro Nano Project is to create a center of excellence in the field of micromechanical engineering with the cooperation of three ULB partners: the CAD-CAM, the Structural and Material Computational Mechanics and the Industrial Chemistry departments.The nanoscale world obeys to different rules than the macroscopic one. Due to the extreme down-scaling many practical problems are encountered in microhandling of small parts. These problems must be studied and solved in order to be able to design and produce reliable micromechanical tools. The CAD-CAM department is in charge of the development of a tool for surface interactions to be able to take into account the surface forces (that are of the outmost importance at nanoscale) for manipulator design and for the development of handling strategies.At small scales the behavior of materials changes significantly with respect to the bulk material at macro-scale, which leaves many unanswered questions. The Structural and Material Computational Mechanics Department is responsible for modeling the mechanical response of materials at nanoscale using appropriate theories to pass from the bulk material parameters to the nanoscale behavior.The previous tasks need inputs from special experiments. The practical research results must also be validated later on. The Industrial Chemistry Department brings its expertise in experimental characterization of materials and performs thorough chemical and physical characterization of materials and surfaces.The project will span five years, with the participation of three PhD students attached to the fore-mentioned three departments during four years and one post-doctoral fellow for the last two years.]

Neofor
Technological platform for advanced pulmonary delivery of Active Pharmaceutical Ingredients [Technological platform for advanced pulmonary delivery of Active Pharmaceutical Ingredients]

Endomina
Endomina

Remaid
Réseaux de micro-aiguilles [Microneedles arrays]



theses


Lambert, P., ''A Contribution to Microassembly: a Study of Capillary Forces as a gripping Principle'', Dir. Prof. A. Delchambre, Faculté des sciences appliquées - Service de mécanique analytique et CFAO, ULB, Bruxelles, 2004

Pierre LAMBERT, A Contribution to Microassembly: a Study of Capillary Forces as a gripping Principle, 2004



prix


Emerald Literati Award (Pierre Lambert)

Second stage of the ERC starting grant (2007)

Paper on acoustic levitation highlighted in Physics Today (September 2011)

Paper highlighted in top 25 papers, Journal of Micromechanics and Microengineering (2011)



disciplines et mots clés déclarés


Automatisme et régulation Biomécanique Biométrie Ingénierie biomédicale Instrumentation médicale Mécanique Médecine chirurgicale Sciences biomédicales Sciences de l'ingénieur

capillary forces délivrance médicament dispositif embarqué electrospray electrostimulation endoscopy estomac etats de surface forces électrostatiques implant large instruments mechanics mechatronics microfluidics micromanipulation microneedles modélisation pylore surface tension transdermal injection tube digestif vibration control