Introduction: Raison d'être of the course
II Non Covalent Interactions
III Importance of Separation Sciences
Ia. HPLC instrumentation and hyphenation to detectors
IIa. Types of Liquid Chromatography
IIIa. Optimization of HPLC separations
IVa. Band broadening in LC
Va. Kinetic performance limits
VIa. Multi-dimensional separations
VIIIa. Gas chromatography
Molecular Structure Characterization
Ib. Spectroscopy: general considerations
IIb. Electronic spectroscopies
IIIb. Vibrational spectroscopies
IVb. Chip Technology
Vb. Mass spectrometry
The aim of the course is to give you insight into the chromatographic methods available for the isolation and purification of molecules of industrial importance. In addition, we aim to teach you the fundamentals and application possibilities of different spectroscopic methods available for the determination and characterization of molecular structures.
Interactive course with powerpoint presentations.
Seminars and practicals illustrate the theory seen during classes.
A copy of the powerpoint slides is available on the Université Virtuelle
HPLC Columns: Theory, Technology, and Practice; U.D. Neue
Contemporary Instrumental Analysis; K.A. Rubinson and J.F. Rubinson
Molecular Structure Determination
Introduction to Organic Spectroscopy; L.M. Harwood and T.D.W Claridge
Oxford Chemistry Primers, Oxford Science Publications (1997)
Molecular Spectroscopy; J.M. Brown
Oxford Chemistry Primers, Oxford Science Publications (1998)
Spectrometric Identification of Organic Compounds; R. M. Silverstein, F. X. Webster
John Wiley & Sons Inc (7th edition, 2005 or any other edition)
Oragnic Structures from Spectra; L.D. Field, S. Sternhell, J.R. Kalman
This teaching unit contributes to the following competences:
In-depth knowledge and understanding of exact sciences with the specificity of their application to (bio)engineering
A creative, problem-solving, result-driven and evidence-based attitude, aiming at innovation and applicability in industry and society
The flexibility and adaptability to work in an international and/or intercultural context
An integrated insight in (bio)chemical process technology and materials' technology
Insight in chemistry as a link between process and materials technology
Written exam, covering all the material seen during classes and the exercise session, accounts for 80% of the final mark.
A graded practical will account for 20 % of the final mark. Modalities will be given during class.
The exercices and practicals illustrate the content of the courses and are as important as the theory.
Prof. Kristin Bartik: firstname.lastname@example.org; Office: P2.2.213 (ULB)
Prof. Sebastiaan Eeltink: email@example.com (VUB)
See university timetables.
Theory: 36 h
Exercises + practicals: 24 h
Questions can be answered during the break or after classes. The practicals are a privileged moment for discussions. It is also possible to make an appointment with the teaching staff to ask further questions.