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{mso-style-name:"Tableau Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} </style> <![endif]--> <meta content="Marc Parmentier" name="author"><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="3074"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--></head> <body style="" background="images/web_body_bg.jpg" bgcolor="#a1c0d8" lang="FR-BE" link="blue" vlink="purple"> <div class="Section1"> <form> <p class="MsoNormal"><!--[if !supportLists]--><span style="font-family: Symbol;" lang="EN-US"><span style="">·<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><!--[endif]--><span style="" lang="EN-US"><o:p>&nbsp;</o:p></span></p> <table class="MsoNormalTable" style="width: 832.8pt;" border="0" cellpadding="0" cellspacing="0" width="1388"> <tbody><tr style=""> <td style="padding: 0cm;" valign="top"><div style="text-align: center;"> </div><div align="center"><div style="text-align: center;"> </div><table class="MsoNormalTable" style="background: white none repeat scroll 0%; width: 510pt; -moz-background-clip: initial; -moz-background-origin: initial; -moz-background-inline-policy: initial;" border="0" cellpadding="0" cellspacing="0" width="850"> <tbody><tr style=""> <td style="padding: 0cm;" valign="top"><div style="text-align: center;"> </div><table class="MsoNormalTable" style="width: 506.4pt;" border="0" cellpadding="0" width="844"> <tbody><tr style=""> <td style="padding: 1.2pt; width: 153pt;" width="255"><p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm; text-align: center;"><span lang="EN-US"><a href="http://www.belspo.be/iap/"><span style="color: windowtext; text-decoration: none;" lang="FR-BE"><img style="width: 162px; height: 236px;" id="_x0000_i1033" src="images/PAI.jpg" border="0"></span></a></span><span style="color: rgb(91, 90, 90);" lang="EN-US"><o:p></o:p></span></p> </td> <td style="padding: 1.2pt; width: 341.4pt; text-align: center;" width="569"><a href="http://www.belspo.be/"><img style="border: 0px solid ; width: 309px; height: 275px;" alt="" src="images/Belspo_en_small.jpg"></a></td> </tr> </tbody></table> <p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm;"><span style="" lang="EN-US"><o:p>&nbsp;</o:p></span></p> <table class="MsoNormalTable" style="width: 507pt;" border="0" cellpadding="0" width="845"> <tbody><tr style=""> <td style="padding: 1.2pt;"> <h1><span style="font-size: 18pt; color: rgb(0, 102, 255);" lang="EN-US">IAP6-14 program 2007-2011</span><span style="font-size: 22pt; color: rgb(0, 102, 255);" lang="EN-US"><o:p></o:p></span></h1> <h1><span style="font-size: 16pt; color: rgb(0, 102, 255);" lang="EN-US">G protein-coupled receptors: from structure to diseases</span><span style="color: rgb(0, 102, 255);" lang="EN-US"><o:p></o:p></span></h1> </td> </tr> </tbody></table> <div style="margin-top: 6pt;"> <div class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; text-align: center; text-indent: 0cm;" align="center"><span style="" lang="EN-US"> <hr align="center" size="2" width="100%"> </span></div> </div> <table class="MsoNormalTable" style="width: 506.4pt;" border="0" cellpadding="0" width="844"> <tbody><tr style=""> <td style="padding: 1.2pt;"> <h1><span style="" lang="EN-US"><a href="index.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Home</span></a></span><span style="font-size: 8pt;" lang="EN-US"> | </span><span style="" lang="EN-US"><a href="Partners.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Partners</span></a></span><span style="font-size: 8pt;" lang="EN-US"> | </span><span style="" lang="EN-US"><a href="Overview.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Program overview</span></a></span><span style="font-size: 8pt;" lang="EN-US"> | </span><span style="" lang="EN-US"><a href="Publications.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Publications</span></a></span><span style="font-size: 8pt;" lang="EN-US"> | </span><span style="" lang="EN-US"><a href="Seminars.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Seminars</span></a></span><span style="font-size: 8pt;" lang="EN-US"> | </span><span style="" lang="EN-US"><a href="Positions.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Open positions&nbsp;</span></a></span><span style="font-size: 8pt;" lang="EN-US">|&nbsp;</span><span style="" lang="EN-US"><a href="Doctoral.html"><span style="font-size: 8pt; font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Doctoral schools</span></a></span><span style="font-size: 8pt;" lang="EN-US"> |&nbsp;<a href="Networks.html"><span style="font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Networks</span></a> |&nbsp;<a href="Intranet.html"><span style="font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Intranet</span></a><u> | <a href="GPCRLinks.html"><span style="font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Links</span></a> | <a href="mailto:mparment@ulb.ac.be"><span style="font-family: &quot;Tahoma&quot;,&quot;sans-serif&quot;; color: rgb(65, 85, 145); font-weight: normal; text-decoration: none;">Contact Us</span></a></u><o:p></o:p></span></h1> </td> </tr> </tbody></table> <p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm;"><span style="" lang="EN-US"><o:p>&nbsp;</o:p></span></p> <table class="MsoNormalTable" style="width: 507.6pt;" border="0" cellpadding="0" width="846"> <tbody><tr style=""> <td style="padding: 1.2pt; width: 24.6pt;" width="41"></td> <td style="padding: 1.2pt; width: 447pt;" width="745"> <h1><span lang="EN-US">Publications of the network</span><span style="" lang="EN-US"><o:p></o:p></span></h1> <h1><span lang="EN-US">2007</span></h1> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P1</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Ballesteros-Yáñez I, Valverde O, Ledent C, Maldonado R, DeFelipe J (2007). Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism. Neuroscience 146:1536-1545.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Bles N, Horckmans M, Lefort A, Libert F, Macours P, El Housni H, Marteau F, Boeynaems JM, Communi D (2007). Gene expression profiling defines ATP as a key regulator of human dendritic cell functions. J Immuno 179:3550-3558.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Boudry C, Markine-Goriaynoff N, Delforge C, Springael JY, de Leval L, Drion P, Russell G, Haig DM, Vanderplasschen AF, Dewals B (2007). The A5 gene of alcelaphine herpesvirus 1 encodes a constitutively active G-protein-coupled receptor that is non-essential for the induction of malignant catarrhal fever in rabbits. J Gen Virol 88:3224-33. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Bura SA, Castañé A, Ledent C, Valverde O, Maldonado R (2007). Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes. Br J Pharmacol 150:758-765.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Corbillé AG, Valjent E, Marsicano G, Ledent C, Lutz B, Hervé D, Girault JA (2007). Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants. J Neurosci 27:6937-6947.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Decaux G, Vandergheynst F, Bouko Y, Parma J, Vassart G, Vilain C (2007). Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree. J am Soc Nephrol 18:606-612.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK (2007). Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115:1581-1590.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I (2007). F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor. J Immunol 178:1450-6.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Hussey MJ, Clarke GD, Ledent C, Hourani SM, Kitchen I (2007). Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice. Pain 129:287-294.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Kellenberger E, Springael JY, Parmentier M, Hachet-Haas M, Galzi JL, Rognan D (2007). Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening. J Med Chem 50:1294-1303.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Makara JK, Katona I, Nyíri G, Németh B, Ledent C, Watanabe M, de Vente J, Freund TF, Hájos N (2007). Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27:10211-10222.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Marcet B, Horckmans M, Libert F, Hassid S, Boeynaems JM, Communi D (2007a). Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells. J Cell Physiol 211:716-727.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Marcet B, Libert F, Boeynaems JM, Communi D (2007b). Extracellular nucleotides induce COX-2 up-regulation and prostaglandin E2 production in human A549 alveolar type II epithelial cells. Eur J Pharmaco 566:167-171.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN (2007). Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13:492-497.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Matos JE, Sorensen MV, Geyti CS, Robaye B, Boeynaems JM, Leipziger J (2007). Distal colonic Na(+) absorption inhibited by luminal P2Y(2) receptors. Pflugers Arch 454:977-987.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Morrison RR, Tan XL, Ledent C, Mustafa SJ, Hofmann PA (2007). Targeted deletion of A2A adenosine receptors attenuates the protective effects of myocardial postconditioning. Am J Physiol Heart Circ Physiol 293:H2523-2529.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Nadeem A, Fan M, Ansari HR, Ledent C, Jamal Mustafa S (2007). Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice. Am J Physiol Lung Cell Mol Physiol 292:L1335-1344.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F, Communi D, Parmentier M, Majorana A, Sironi M, Tabellini G, Moretta A, Sozzani S (2007). The role of chemerin in the co-localization of NK and dendritic cell subsets into inflamed tissues. Blood 109:3625-3632 </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M and Spedding M (2007). International Union of basic and clinical pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev 59:5-13.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Popoli P, Blum D, Martire A, Ledent C, Ceruti S, Abbracchio MP (2007). Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease. Prog Neurobiol 81:331-348.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Proost P, Mortier A, Loos T, Vandercappellen J, Gouwy M, Ronsse I, Schutyser E, Put W, Parmentier M, Struyf S, Van Damme J (2007). Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signalling and reduces lymphocyte and endothelial cell migration. Blood 110:37-44.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S (2007). Chemerin-A new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 362:1013-1018.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M (2007). Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics 8:177.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="font-family: Symbol;" lang="EN-US"><span style=""><span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;"></span></span></span><span lang="EN-US">Sohy D, Parmentier M, Springael JY (2007). Allosteric trans-inhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem 282:30062-30069.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Springael JY, de Poorter C, Deupi X, Van Durme J, Pardo L, Parmentier M (2007). </span><span lang="EN-US">The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin. Cell Signal 19:1446-1456. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Springael JY, Urizar E, Costagliola S, Vassart G, Parmentier M (2007). Allosteric properties of G protein-coupled receptor oligomers. Pharmacol Ther 115:410-418. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Sutherland A, Mirjolet JF, Maho A, Parmentier M (2007). Expression of the chemokine receptor CCR6 in the Lewis lung carcinoma (LLC) cell line reduces its metastatic potential in vivo. Cancer Gene Ther 14:847-857. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Thiemann G, Fletcher BC, Ledent C, Molleman A, Hasenöhrl RU (2007). The genetic versus pharmacological invalidation of the cannabinoid CB1 receptor results in differential effects on 'non-associative' memory and forebrain monoamine concentrations in mice. Neurobiol Learn Mem 88:416-423.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Twizere JC, Springael JY, Boxus M, Burny A, Dequiedt F, Dewulf JF, Duchateau J, Portetelle D, Urbain P, Van Lint C, Green PL, Mahieux R, Parmentier M, Willems L, Kettmann R (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G protein signaling. Blood 109:1051-60.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Loy T, Van Hiel MB, Vandersmissen HP, Poels J, Mendive F, Vassart G, Vanden Broeck J (2007). Evolutionary conservation of bursicon in the animal kingdom. Gen Comp Endocrinol 153:59-63.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Warnault V, Houchi H, Barbier E, Pierrefiche O, Vilpoux C, Ledent C, Daoust M, Naassila M (2007). The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABAA receptors after chronic ethanol exposure. J Neurochem 102:741-752.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P2</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Badisco, L., Claeys, I., Van Loy, T., Van Hiel, M., Franssens, V., Simonet, G., &amp; Vanden Broeck, J. (2007) Neuroparsins, a family of conserved arthropod neuropeptides. Gen. Comp. Endocrinol., 153, 64-71. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Cnops, L., Hu, T-T., Vanden Broeck, J., Burnat, K., Van den Bergh, G., &amp; Arckens, L. (2007) Age- and experience-dependent expression of Dynamin I and Synaptotagmin I in cat visual system. J. Comp. Neurol., 504, 254-264. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Fichna, J., do-Rego, J.C., Chung, N.N., Schiller, P.W., Poels, J., Vanden Broeck, J., Costentin, J., &amp; Janecka, A. (2007) Synthesis and characterization of potent and selective µ-opioid receptor antagonists, antanal-1 and antanal-2. J. Med. Chem., 50, 512-520. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Fichna, J., Staniszewska, R., Poels, J., Vanden Broeck, J., &amp; Janecka, A. (2007) mu-opioid receptor ligands lack receptor subtype selectivity in the aequorin luminescence-based calcium assay. Chem. Biol. Drug. Des., 70, 247-253. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Husson, S.J., Mertens, I., Janssen, T., Lindemans, M., &amp; Schoofs L. (2007) Neuropeptidergic signaling in the nematode Caenorhabditis elegans. Prog. Neurobiol., 82, 33-55. Review. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Larhammar, D., &amp; Vanden Broeck, J. (2007) Peptide hormone and receptor evolution. Gen. Comp. Endocrinol., 153, 147. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Poels, J., Verlinden, H., Fichna, J., Van Loy, T., Franssens, V., Studzian, K., Janecka, A., Nachman, R.J., &amp; Vanden Broeck, J. (2007) Functional comparison of two evolutionary conserved insect neurokinin-like receptors. Peptides, 28, 103-108. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Sas, F., Begum, M., Vandersmissen, T., Geens, M., Claeys, I., Van Soest, S., Huybrechts, J., Huybrechts, R., &amp; De Loof, A. 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(2008) The role of hemocytes, serine protease inhibitors and pathogen-associated patterns in prophenoloxidase activation in the desert locust, Schistocerca gregaria.<span style="">&nbsp; </span>Peptides 29, 235-241. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Janssen, T., Husson, S.J., Lindemans, M., Mertens, I., Rademakers, S., Ver Donck, K., Geysen, J., Jansen, G., Schoofs, L. (2008) Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans. J. Biol. Chem. 283,15241-15249. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Janssen, T., Meelkop, E., Lindemans, M., Verstraelen, K., Husson, S.J., Temmerman, L., Nachman, R.J., Schoofs, L. (2008) Discovery of a cholecystokinin-gastrin-like signaling system in nematodes. 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Acta Microbiol Immunol Hung. 55, 75-89.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="NL">Van de Velde S, Thevelein JM. </span><span lang="EN-US">(2008) Cyclic AMP-protein kinase A and Snf1 signaling mechanisms underlie the superior potency of sucrose for induction of filamentation in Saccharomyces cerevisiae. </span><span style="" lang="NL">Eukaryot Cell<span style="">&nbsp; </span>7, 286-293.<o:p></o:p></span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P4</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="NL">Abu El-Asrar AM, Struyf S, Van Damme J, Geboes K (2008). </span><span lang="EN-US">Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes. Br J Ophthalmol 92:699-704.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="NL">Gouwy M, Struyf S, Noppen S, Schutyser E, Springael JY, Parmentier M, Proost P, Van Damme J (2008). </span><span lang="EN-US">Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol Pharmacol 74:485-495.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Loos T, Mortier A, Gouwy M, Ronsse I, Put W,<span style="">&nbsp; </span>Lenaerts JP, Van Damme J, Proost P (2008). Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. </span><span style="" lang="NL">Blood 112:2648-2656.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Mortier A, Van Damme J, Proost P (2008). Regulation of chemokine activity by posttranslational modification. Pharmacol Ther 120:197-217.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US"><span style="">&nbsp;</span>Proost P, Loos T, Mortier A, Schutyser E, Gouwy M, Noppen S, Dillen C, Ronsse I, Conings R, Struyf S, Opdenakker G, Maudgal PC, Van Damme J (2008). Citrullination of CXCL8 by peptidylarinine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. </span><span style="" lang="NL">J Exp Med 205:2085-2097.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Den Steen PE, Deroost K, Van Aelst I, Geurts N, Martens E, Struyf S, Nie CQ, Hansen DS, Matthys P, Van Damme J, Opdenakker G (2008). CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-³-induced chemokines. </span><span style="" lang="NL">Eur J Immunol 38:1082-1095.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="NL">Vandercappellen J, Van Damme J, Struyf S (2008). </span><span lang="EN-US">The role of CXC chemokines and their receptors in cancer. Cancer Letters 267:226-244.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P5</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="DE">Vanden Bergh P, Zecchinon L, Fett T, Desmecht D (2008).<span style="">&nbsp; </span></span><span lang="EN-US">Probing of <i>Actinobacillus pleuropneumoniae</i> ApxIIIA toxin-dependent cytotoxicity towards mammalian peripheral blood mononucleated cells. <i>BMC Research Notes</i> 1:121.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Fett T, Zecchinon L, Vanden Bergh P, D. Desmecht D (2008).<i style=""><span style="">&nbsp;&nbsp; </span>Mannheimia haemolytica</i> leukotoxin-induced cytolysis of caprine (<i style="">Capra hircus</i>) leukocytes is mediated by the CD18 subunit of </span><span style="font-family: Symbol;" lang="EN-US">b</span><sub><span lang="EN-US">2</span></sub><span lang="EN-US">-integrins. <i>Microbial Pathogenesis</i> 45:337-342.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Antoine-Moussiaux N, Magez S, Desmecht D (2008). </span><span lang="EN-US">Contributions of experimental mouse models to the understanding of African trypanosomiasis. <i>Trends in Parasitology</i> 24 : 411-418.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Desmecht D, Vanden Bergh R, Sartelet A, Leclerc M, Mignot C, Misse F, Sudraud C, Berthemin S, Jolly S, Mousset B, Linden A, Coignoul F, Cassart D (2008). Evidence for transplacental transmission of the current wild-type strain of bluetongue virus serotype-<st1:metricconverter productid="8 in" w:st="on">8 in</st1:metricconverter> cattle.<span style="">&nbsp; </span><i>The Veterinary Record</i> 163 : 50-52.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Antoine-Moussiaux N, Saerens D, Desmecht D (2008). </span><span lang="EN-US">Flow cytometric enumeration of parasitaemia and haematologic changes in trypanosoma-infected mice.<span style="">&nbsp; </span><i style="">Acta Tropica</i> 107 : 139-144.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Vanden Bergh P, Fett T, Zecchinon L, Desmecht D (2008). Les facteurs de virulence d Actinobacillus pleuropneumoniae, l agent étiologique de la pleuropneumonuie porcine.<span style="">&nbsp; </span><i>Annales de Médecine vétérinaire</i>, 152&nbsp;: 74-96, 2008<o:p></o:p></span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner EU1</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="IT">Bakker RA, A. Jongejan, K. Sansuk, U. Hacksell, H. Timmerman, M.R. Brann, D.M. Weiner, L. Pardo, R. Leurs. </span><span lang="EN-US">Constitutively active mutants of the histamine H<sub>1</sub> receptor suggest a conserved hydrophobic asparagine-cage that constraints the activation of class A GPCRs. <i style="">Molecular Pharmacology,</i> 73, 94-103 (2008)</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="ES">Caltabiano G, M. Campillo, A. De Leener, G. Smits, G. Vassart, S. Costagliola, L. Pardo. </span><span lang="EN-US">The specificity of binding of glycoprotein hormones to their receptors. <i style="">Cellular and Molecular Life Sciences</i>, <u>65</u>, 2484-2492 (2008)</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="ES">De Leener A, G. Caltabiano, S. Erkan, M. Idil, G. Vassart, L. Pardo, S. Costagliola. </span><span lang="EN-US">Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible of spontaneous ovarian hyperstimulation syndrome. <i style="">Human Mutation</i>, <u>29</u>, 91-98 (2008)</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="" lang="ES">Medina RA, J. Sallander, B. Benhamú, E. Porras, M. Campillo, L. Pardo, M. L. López-Rodríguez. </span><span lang="EN-US">Synthesis of new serotonin 5-HT<sub>7</sub> receptor ligands. 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PLoS One 4(3):e4704. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Loy T, Vandersmissen HP, Poels J, Van Hiel MB, Verlinden H, Vanden Broeck J (2010). Tachykinin-related peptides and their receptors in invertebrates: a current view.<span style="">&nbsp; </span>Peptides, 31: 520-524. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Vassart G (2010). An in vivo demonstration of functional G protein-coupled receptor dimers. Proc Natl Acad Sci USA 107:1819-1820.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy AP (2009). International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family. Pharmacol Rev 61:119-161.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P2</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Breugelmans B, Simonet G, van Hoef V, Van Soest S, Smagghe G, Vanden Broeck J (2009). A lepidopteran pacifastin member: cloning, gene structure, recombinant production, transcript profiling and in vitro activity.<span style="">&nbsp; </span>Insect Biochem Mol Biol 39: 430-439. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Breugelmans B, Simonet G, van Hoef V, Van Soest S, Vanden Broeck J (2009). Pacifastin-related peptides: structural and functional characteristics of a family of serine peptidase inhibitors.<span style="">&nbsp; </span>Peptides 30: 622-632. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Breugelmans B, Simonet G, van Hoef V, Van Soest S, Vanden Broeck J (2009). Identification, distribution and molecular evolution of the pacifastin gene family in Metazoa.<span style="">&nbsp; </span>BMC Evol Biol 9: 97. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Clynen E, Schoofs L (2009). Peptidomic survey of the locust neuroendocrine system.<span style="">&nbsp; </span>Insect Biochem Molec Biol 39: 491-507.<span style="">&nbsp; </span></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Clynen E, Husson S, Schoofs L (2009). Identification of new members of the (short) neuropeptide F family in locusts and Caenorhabditis elegans.<span style="">&nbsp; </span>Ann N Y Acad Sci 1163: 60-74. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Janssen T, Husson S, Meelkop E, Temmerman L, Lindemans M, Verstraelen K, Rademakers S, Mertens I, Nitabach M, Jansen G, Schoofs L (2009). Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.<span style="">&nbsp; </span>J Neurochem 111: 228-241. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Janssen T, Meelkop E, Nachman R, Schoofs L (2009). Evolutionary conservation of the cholecystokinin/gastrin signaling system in nematodes.<span style="">&nbsp; </span>Ann N Y Acad Sci 1163: 428-432. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Lindemans M, Janssen T, Husson S, Meelkop E, Temmerman L, Clynen E, Mertens I, Schoofs L (2009). A neuromedin-pyrokinin-like neuropeptide signaling system in Caenorhabditis elegans.<span style="">&nbsp; </span>Biochem Biophys Res Commun 379: 760-764. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Lindemans M, Liu F, Janssen T, Husson S, Mertens I, Gäde G, Schoofs L (2009). Adipokinetic hormone signaling through the gonadotropin-releasing hormone receptor modulates egg-laying in Caenorhabditis elegans.<span style="">&nbsp; </span>Proc Natl Acad Sci USA 106: 1642-1647. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Poels J, Birse RT, Nachman RJ, Fichna J, Janecka A, Vanden Broeck J, Nässel DR (2009). Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6. Peptides 30: 545-556. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Verleyen P, Chen X, Baron S, Preumont A, Hua Y, Schoofs L, Clynen E (2009). Cloning of neuropeptide-like precursor 1 in the grey flesh fly and peptide identification and expression.<span style="">&nbsp; </span>Peptides 30: 522-530.<span style="">&nbsp; </span></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Verleyen P, Huybrechts J, Schoofs L (2009) SIFamide illustrates the rapid evolution in arthropod neuropeptide research.<span style="">&nbsp; </span>Gen Comp Endocrinol 162: 27-35. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Verlinden H, Badisco L, Marchal E, Van Wielendaele P, Vanden Broeck J (2009). Endocrinology of reproduction and phase transition in locusts.<span style="">&nbsp; </span>Gen Comp Endocrinol 162/ 79-92. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Hiel MB, Van Wielendaele P, Temmerman L, Van Soest S, Vuerinckx K, Huybrechts R, Vanden Broeck J, Simonet G (2009). Identification and validation of housekeeping genes in brains of the desert locust Schistocerca gregaria under different developmental conditions.<span style="">&nbsp; </span>BMC Mol Biol 10: 56. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Boerjan B, Verleyen P, Huybrechts J, Schoofs L, De Loof A (2010). In search for a common denominator for the diverse functions of arthropod corazonin: a role in the physiology of stress?<span style="">&nbsp; </span>Gen Comp Endocrinol 166, 222-233. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">De Loof A, Huybrechts J, Geens M, Vandersmissen T, Boerjan B, Schoofs L (2010). Sexual differentiation in adult insects: Male-specific cuticular yellowing in Schistocerca gregaria as a model for reevaluating some current (neuro)endocrine concepts.<span style="">&nbsp; </span>J Insect Physiol, in press. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Marchal E, Vandersmissen HP, Badisco L, Van de Velde S, Verlinden H, Iga M, Van Wielendaele P, Huybrechts R, Simonet G, Smagghe G, Vanden Broeck J (2010). Control of ecdysteroidogenesis in prothoracic glands of insects: a review.<span style="">&nbsp; </span>Peptides 31: 506-519. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Perlikowska R, Fichna J, Wyrebska A, Poels J, Vanden Broeck J, Toth G, Storr M, do Rego JC, Janecka A (2010): Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2.<span style="">&nbsp; </span>Basic Clin Pharmacol Toxicol 106: 106-113. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Poels J, Van Loy T, Vandersmissen HP, Van Hiel MB, Van Soest S, Nachman RJ, Vanden Broeck J (2010). Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor.<span style="">&nbsp; </span>Cell Mol Life Sci, in press. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Loy T, Vandersmissen HP, Poels J, Van Hiel MB, Verlinden H, Vanden Broeck J (2010). Tachykinin-related peptides and their receptors in invertebrates: a current view.<span style="">&nbsp; </span>Peptides 31: 520-524. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Verlinden H, Vleugels R, Marchal E, Badisco L, Tobback J, Pflüger HJ, Blenau W, Vanden Broeck J (2010). The cloning, phylogenetic relationship and distribution pattern of two new putative GPCR-type octopamine receptors in the desert locust (Schistocerca gregaria).<span style="">&nbsp; </span>J Insect Physiol, in press. </span></p> <h3 style="margin-left: 17.85pt; text-indent: 0cm;"><span lang="EN-US"><span style="">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>Book chapters:</span></h3> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van de Velde* S, Badisco* L, Marchal* E, Vanden Broeck J, Smagghe G (2009). Diversity in factors regulating ecdysteroidogenesis in insects.<span style="">&nbsp; </span>In: ''Ecdysone, structures and functions''.<span style="">&nbsp; </span>Edited by: Guy Smagghe.<span style="">&nbsp; </span>Chapter 11, p.283-315.<span style="">&nbsp; </span>Springer Science (ISBN: 978-1-4020-9111-7).<span style="">&nbsp; </span></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Hiel MB, Van Loy T, Poels J, Vandersmissen HP, Verlinden H, Badisco L, Vanden Broeck J (2010) Neuropeptide receptors as possible targets for development of insect pest control agents.<span style="">&nbsp; </span>In: "Neuropeptide Systems as Targets for Parasite and Pest Control".<span style="">&nbsp; </span>Edited by: Timothy G Geary and Aaron G Maule<span style="">&nbsp; </span>Landes Bioscience (in press).<span style="">&nbsp;&nbsp;&nbsp; </span></span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; &nbsp;Partner P3</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Lundh F, JM Mouillon, D Samyn, K Stadler, Y Popova, JO Lagerstedt, JM Thevelein and BL Persson (2009). Molecular mechanisms controlling phosphate-induced down-regulation of the yeast Pho84 phosphate transporter. Biochemistry 48: 4497-4505</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Popova Y, P Thayumanavan, E Lonati, M Agrochão and JM Thevelein (2010). Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor. Proc Natl Acad Sci USA 107: 2890-2895.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Rubio-Texeira M, Van Zeebroeck G, Voordeckers K and Thevelein JM (2010). Saccharomyces cerevisiae plasma membrane nutrient sensors and their role in PKA signaling. FEMS Yeast Research 10: 134-149.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Thevelein JM and K Voordeckers (2009). Functioning and evolutionary significance of nutrient transceptors. Molecular Biology &amp; Evolution 26: 2407-2414.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Dijck, P (2009). Nutrient sensing G protein coupled receptors: interesting targets for antifungals? Med Mycol 47:671-680.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Van Zeebroeck G, B Monge Bonini, M Versele and JM Thevelein (2009). Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nature Chem Biol 5: 45-52.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P4</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Enderlin M, EV Kleinmann, S Struyf, C Buracchi, A Vecchi, R Kinscherf, F Kiessling, S Paschek, S Sozzani, J Rommelaere, JJ Cornelis, J Van Damme and C Dinsart (2009). TNF-</span><span style="font-family: Symbol;" lang="EN-US">a</span><span lang="EN-US"> and the IFN-</span><span style="font-family: Symbol;" lang="EN-US">g</span><span lang="EN-US">-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma. Cancer Gene Ther 16: 149-160.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Gouwy M, S Struyf, H Verbeke, W Put, P Proost, G Opdenakker and J Van Damme (2009). CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8. J Leukoc Biol 86: 671-680.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Kelchtermans H, E Schurgers, L Geboes, T Mitera, J Van Damme, J Van Snick, C Uyttenhove and P Matthys (2009). Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma. Arthritis Res Ther 11: R122.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Loos T, G Opdenakker, J Van Damme and P Proost (2009).Citrullination of CXCL8 increases this chemokine s ability to mobilize neutrophils into the blood circulation. Haematologica 94: 1346-1353. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Michiels K, E Schutyser, R Conings, JP Lenaerts, W Put, S Nuyts, P Delaere, R Jacobs, S Struyf, P Proost &amp; J Van Damme (2009). Carcinoma cell-derived chemokines and their presence in oral fluid. Eur J Oral Sci 117 : 362-368.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Qiu Z, C Dillen, J Hu, H Verbeke, S Struyf, J Van Damme and G Opdenakker (2009). Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. Immunobiology 214: 835-842.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Sliepen I, J Van Damme, M Van Essche, G Loozen, M Quirynen and W Teughels (2009). Microbial interactions influence inflammatory host cell responses. J Dent Res 88: 1026-1030.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Struyf S, S Noppen, T Loos, A Mortier, M Gouwy, H Verbeke, D Huskens, S Luangsay, M Parmentier, K Geboes, D Schols, J Van Damme and P Proost (2009). Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J Immunol 182: 666-674.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Struyf S, P Proost, J Vandercappellen, S Dempe, B Noyens, S Nelissen, M Gouwy, M Locati, G Opdenakker, C Dinsart and J Van Damme (2009). Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects. Eur J Immunol 39: 843-857. </span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Vandercappellen J, S Liekens, A Bronckaers, S Noppen, I Ronsse, C Dillen, M Bellen, S Mitola, P Proost, M Presta, S Struyf and J Van Damme (2010). The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo. Mol Cancer Res 8, in press.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Verbeke H, G De Hertogh, S Li, J Vandercappellen, S Noppen, E Schutyser, A Abu El-Asrar, G Opdenakker, J Van Damme, K Geboes and S Struyf (2010). Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer. Human Pathol, in press.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner P5</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Antoine-Moussiaux N, Büscher P, Desmecht D (2009). </span><span lang="EN-US">Host-parasite interactions in trypanosomiasis: on the way to an antidisease strategy. Infect Immun 77: 1276-1284.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Antoine-Moussiaux N, Cornet A, Cornet F, Glineur S, Dermine M, Desmecht D (2009). A non-cytosolic protein of Trypanosoma evansi induces CD45-dependent lymphocyte death. </span><span style="">PLoS One 4 :e5728.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Bondue B, Glineur S, De Nadai P, De Henau O, Communi D, De Vuyst P, Desmecht D and Parmentier M (2010). </span><span lang="EN-US">Essential role of ChemR23 for plasmacytoid dendritic cell recruitment and anti-viral immunity in a mouse model of viral pneumonia. In revision</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Garigliany MM, Cloquette K, Leroy M, Decreux A, Goris N, De Clercq K, Desmecht D (2009). Modulating mouse innate immunity to RNA viruses by expressing the Bos taurus Mx system. Transgenic Res 18: 719-732.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Garigliany MM, Habyarimana A, Lambrecht B, Van de Paar E, Cornet A, van den Berg T, Desmecht D (2010). Influenza A strain-dependent pathogenesis in fatal H1N1 and H5N1 subtype infections of mice. </span><span style="">Emerg Infect Dis 16: 595-603.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">Habyarimana JB, Flandre T, Faisca P, Antoine-Moussiaux N, Desmecht D (2009). </span><span lang="EN-US">A critical appraisal of carbon monoxide uptake measurements for the follow-up of experimental respiratory diseases in the laboratory mouse. Scand JK Lab Anim Sci 36: 229-240.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Palm M, Garigliany MM, Cornet F, Desmecht D (2010). Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles. Vet Res 41: 29-37.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Vanden Bergh PG, Zecchinon LL, Fett T, Desmecht D (2009). Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity. Vet Res 40: 33-40.</span></p> <h2><span lang="EN-GB">&nbsp; &nbsp; Partner EU1</span></h2> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK (2010). Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 463:108-112.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span style="">de la Fuente T, Martín-Fontecha M, Sallander J, Benhamú B, Campillo M, Medina RA, Pellissier LP, Claeysen S, Dumuis A, Pardo L, López-Rodríguez ML (2010). </span><span lang="EN-US">Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem 53:1357-1369.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Deupi X, Olivella M, Sanz A, Dölker N, Campillo M, Pardo L (2010). Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices. J Struct Biol 169:116-123.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK (2009). Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. EMBO J 28:3315-3328.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML (2009). Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J Med Chem 52:2384-2392.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Pellissier LP, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L (2009). Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol 75:982-990.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E (2009). The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem 284:1324-1336.</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B (2009). The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proceedings of the National Academy of Science USA, 106, 9501 9506 (2009)</span></p> <p class="MsoNormal" style="margin-left: 47.35pt; text-indent: -18pt;"><span lang="EN-US">Ye S, Zaitseva E, Caltabiano G, Schertler GF, Sakmar TP, Deupi X, Vogel R (2010). Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature 464:1386-1389.</span></p> </td> <td style="padding: 1.2pt; width: 24pt;" width="40"></td> </tr> </tbody></table> <p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm;"><span style="" lang="EN-US"><o:p>&nbsp;</o:p></span></p> <div style="margin-top: 6pt;"> <div class="MsoNormal" style="margin: 0cm 0cm 0.0001pt; text-align: center; text-indent: 0cm;" align="center"><span style="" lang="EN-US"> <hr align="center" size="2" width="100%"> </span></div> </div> <table class="MsoNormalTable" style="width: 507.6pt;" border="0" cellpadding="0" width="846"> <tbody><tr style=""> <td style="padding: 1.2pt; width: 114.6pt;" width="191"> <p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm;"><span style=""><img id="_x0000_i1031" src="images/ulbnorm.jpg" border="0" height="120" width="120"></span><span style="" lang="EN-US"><o:p></o:p></span></p> </td> <td style="padding: 1.2pt; width: 102pt;" width="170"> <p class="MsoNormal" style="margin-left: 0cm; text-indent: 0cm;"><span style=""><img id="_x0000_i1030" src="images/logo-kuleuven.gif" border="0" height="54" width="161"></span><span style="" lang="EN-US"><o:p></o:p></span></p> </td> <td style="padding: 1.2pt; 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