IAP7-40   GPCRs

Home  -  Partners  -  Program overview  -  Publications  -  Conferences & meetings  -  Open positions  -  Links  -  Contacts

Publications of the network


Chesworth R, Brown RM, Kim JH, Ledent C, Lawrence AJ (2016). Adenosine 2A receptors modulate reward behaviours for methamphetamine. Addict Biol 21:407-21.

Claes K, Vandewalle K, Laukens B, Laeremans T, Vosters O, Langer I, Parmentier M, Steyaert J, Callewaert N (2016). Modular integrated secretory system engineering in Pichia pastoris to enhance G-protein coupled receptor expression. ACS Synth Biol  [Epub ahead of print]

Correa M, Pardo M, Bayarri P, López-Cruz L, San Miguel N, Valverde O, Ledent C, Salamone JD (2016). Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine AAKO mice. Psychopharmacology (Berl) 233:393-404.

De Buck M, Gouwy M, Wang J, Van Snick J, Opdenakker G, Struyf S, Van Damme J (2016). Structure and expression of different serum amyloid A (SAA) variants and their concentration-dependent functions during host insults. Current Med Chem, In Press.

De Buck M, Gouwy M, Wang J, Van Snick J, Proost P, Struyf S, Van Damme J (2016). The cytokine-serum amyloid A-chemokine network. Cytokine & Growth Factor Reviews, In Press.

DeVree B, Mahoney J, Velez-Ruiz G, Rasmussen S, Kuszak A, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt R, Pardon E, Steyaert J, Kobilka B, Sunahara R (2016). Allosteric coupling from G protein to the agonist binding pocket in GPCRs. Nature, in press.

Dillen S, Chen Z, Vanden Broeck J (2016). Nutrient-dependent control of short neuropeptide F transcript levels via components of the insulin/IGF signaling pathway in the desert locust, Schistocerca gregaria. Insect Biochem Mol Biol 68: 64-70.

Fernandez-Vallone VF, Leprovots M, Strollo S, Vasile G, Lefort A, Libert F, Vassart G, Garcia MI (2016). Trop2 marks transient gastric fetal epithelium and adult regenerating  cells after epithelial damage. Development [Epub ahead of print].

Gagliostro V, Seeger P, Garrafa E, Salvi V, Bresciani R, Bosisio D, Sozzani S (2016). Pro-lymphangiogenic properties of IFN-γ-activated human dendritic cells. Immunol Lett 173: 26-35.

Haanes KA, Spray S, Syberg S, Jørgensen NR, Robaye B, Boeynaems JM, Edvinsson L (2016). New insights on pyrimidine signalling within the arterial vasculature – Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse. J Mol Cell Cardiol 93: 1-11.

Labazi H, Tilley SL, Ledent C, Mustafa SJ (2016). Role of adenosine receptor(s) in the control of vascular tone in the mouse pudendal artery. J Pharmacol Exp Ther 356: 673-80.

Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Marciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D (2016). A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Mol Psychiatry 21: 97-107. Erratum in Mol Psychiatry 21: 149.

Manglik A, Kobilka BK, Steyaert J (2016). Nanobodies to study G protein-coupled receptor structure and function. Annu Rev Pharmacol Toxicol 57 (in press).

Mazzon C, Zanotti L, Wang L, Del Prete A, Fontana E, Salvi V, Poliani PL, Sozzani S (2016). CCRL2 regulates M1/M2 polarization during EAE recovery phase. J Leukoc Biol [Epub ahead of print].

Mortier A, Gouwy M, Van Damme J, Proost P, Struyf S (2016). CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology. J Leukocyte Biol, In Press.

Nässel DR, Vanden Broeck J (2016). Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides.  Cellular and Molecular Life Sciences 73 : 271-290.

Nishimura A, Sunggip C, Tozaki-Saitoh H, Shimauchi T, Numaga-Tomita T, Hirano K, Ide T, Boeynaems JM, Kurose H, Tsuda M, Robaye B, Inoue K, Nishida M (2016). Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension. Sci Signal 9:ra7.

Peyrassol X, Laeremans T, Gouwy M, Lahura V, Debulpaep M, Van Damme J, Steyaert J, Parmentier M, Langer I (2016). Development by Genetic Immunization of Monovalent Antibodies (Nanobodies). Behaving as Antagonists of the Human ChemR23 Receptor. J Immunol 196: 2893-901.

Put K, Brisse E, Avau A, Imbrechts M, Mitera T, Janssens R, Proost P, Fallarino F, Wouters CH, Matthys P (2016). IDO1 deficiency does not affect disease in mouse models of systemic juvenile idiopathic arthritis and secondary hemophagocytic lymphohistiocytosis. PLoS One 11: e0150075.

Rosière R, Van Woensel M, Mathieu V, Langer I, Mathivet T, Vermeersch M, Amighi K, Wauthoz N (2016). Development and evaluation of well-tolerated and tumor-penetrating polymeric micelle-based dry powders for inhaled anti-cancer chemotherapy. Int J Pharm 501: 148-159.

Staus DP, Stracha RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ (2016). Allosteric nanobodies reveal the dynamic range and diverse mechanisms of GPCR activation. Nature, in press.

Taguchi M, Shinozaki Y, Kashiwagi K, Shigetomi E, Robaye B, Koizumi S (2016). Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y6 receptor signals. J Neurochem [Epub ahead of print]

van der Woning B, De Boeck G, Blanchetot C, Bobkov V, Klarenbeek A, Saunders M, Waelbroeck M, Laeremans T, Steyaert J, Hultberg A, De Haard H (2016). DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops. Mabs [Epub ahead of print].

Vanheule V, Janssens R, Boff D, Kitic N, Berghmans N, Ronsse I, Kungl A, Amaral F, Teixeira M, Van Damme J, Proost P, Mortier A (2016). The positively charged COOH-terminal glycosaminoglycan-binding CXCL9(74-103) peptide inhibits CXCL8-induced neutrophil extravasation and monosodium urate Crystal-induced Gout in Mice. J Biol Chem 290: 21292-304

Vanheule V, Vervaeke P, Mortier A, Noppen S, Gouwy M, Snoeck R, Andrei G, Van Damme J, Liekens S, Proost P (2016). Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus. Biochem Pharmacol 100: 73-85

Wright SR, Zanos P, Georgiou P, Yoo JH, Ledent C, Hourani SM, Kitchen I, Winsky-Sommerer R, Bailey A (2016). A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine. Addict Biol [Epub ahead of print].



Abu El-Asrar A, De Hertogh G, van den Eynde K, Alam K, Van Raemdonck K, Opdenakker G, Van Damme J, Geboes K, Struyf S (2015). Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). Exp Eye Res 132: 179-189.

Abu El-Asrar A, Mohammad G, Nawaz M, Abdelsaid M, Siddiquei M, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S (2015) The chemokine platelet factor-4 variant (PF-4var)/CXCL4L1 inhibits diabetes-induced blood-retinal barrier breakdown. Investigative Ophthalmol & Vis Sci 56: 1956-1964.

Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M (2015). An atypical addition to the chemokine receptor nomenclature: IUPHAR review 15. Br J Pharmacol 172:945-3949.

Betti C, Starnowska J, Mika J, Dyniewicz J, Frankiewicz L, Novoa A, Bochynska M, Keresztes A, Kosson P, Makuch W, Van Duppen J, Chung N, Vanden Broeck J, Lipkowski A, Schiller P, Janssen F, Ceusters M, Sommen F, Meert T, Przewlocka B, Tourwé D, Ballet S (2015). Dual alleviation of acute and neuropathic pain by fused opioid agonist - neurokinin 1 antagonist peptidomimetics. ACS Medicinal Chemistry Letters 6: 1209-1214.

Bitencourt RM, Alpár A, Cinquina V, Ferreira SG, Pinheiro BS, Lemos C, Ledent C, Takahashi RN, Sialana FJ, Lubec G, Cunha RA, Harkany T, Köfalvi A (2015). Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents. Neurochem Int 90:2-84.

Boeckstaens M, Merhi A, Llinares E, Van Vooren P, Springael JY, Wintjens R, Marini AM (2015). Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32. PLoS Genet 11:1005382.

Bondue B, Sherer F, Van Simaeys G, Doumont G, Egrise D, Yakoub Y, Huaux F, Parmentier M, Rorive S, Sauvage S, Lacroix S, Vosters O, De Vuyst P, Goldman S (2015). PET/CT with 18F-FDG- and 18F-FBEM-labeled leukocytes for metabolic activity and leukocyte recruitment monitoring in a mouse model of pulmonary fibrosis. J Nucl Med 56:27-132.

Corbisier J, Galès C, Huszagh A, Parmentier M, Springael JY (2015). Biased signaling at chemokine receptors. J Biol Chem 290: 9542-9554.

De Buck M, Berghmans N, Pörtner N, Vanbrabant L, Cockx M, Struyf S, Opdenakker G, Proost P, Van Damme J, Gouwy M (2015). Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. J Leukocyte Biol 98: 1049-1060

Del Prete A, Luganini A, Scutera S, Rossi S, Anselmo A, Greco D, Landolfo S, Badolato R, Gribaudo G, Sozzani S, Musso T (2015). Interferon-α production by plasmacytoid dendritic cells is dispensable for an effective anti-cytomegalovirus response in adaptor protein-3-deficient mice. J Interferon Cytokine Res 35: 232-238.

Dillen S, Chen Z, Vanden Broeck J (2015). Assaying Visual Memory in the Desert Locust. Insects 6 : 409-418.

Dumont J, Opitz R, Christophe D, Vassart G, Roger PP, Maenhaut C (2015). Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext South Dartmouth (MA): MDText.com, Inc.

Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F (2015). Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats. Dis Model Mech 8: 57-63.

Ferreira SG, Gonçalves FQ, Marques JM, Tomé ÂR, Rodrigues RJ, Nunes-Correia I, Ledent C, Harkany T, Venance L, Cunha RA, Köfalvi A (2015). Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. Br J Pharmacol 172: 1074-1086.

Golovko T, Min R, Lozovaya N, Falconer C, Yatsenko N, Tsintsadze T, Tsintsadze V, Ledent C, Harvey RJ, Belelli D, Lambert JJ, Rozov A, Burnashev N (2015). Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors. Cereb Cortex 25: 2440-2455.

Gouwy M, De Buck, M, Pörtner N, Opdenakker G, Proost P, Struyf S, Van Damme J. (2015) Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. Eur J Immunol 45: 101-112.

Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, Van Duppen J, Przewlocka B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S (2015). Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. Eur J Med Chem 92C: 64-77.

Horckmans M, Esfahani H, Beauloye C, Clouet S, di Pietrantonio L, Robaye B, Balligand JL, Boeynaems JM, Dessy C, Communi D (2015). Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation. J Immunol 194:874-1881.

Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK (2015). Structural insights into µ-opioid receptor activation. Nature 524:15-321

Kankipati HN, Rubio-Texeira M, Castermans D, Diallinas G, Thevelein JM (2015). Sul1 and Sul2 sulfate transceptors signal to protein kinase A upon exit of sulfur starvation. J Biol Chem 290: 10430-10446.

Lan TH, Liu Q, Li C, Wu G, Steyaert J, Lambert NA (2015). BRET evidence that β2 adrenergic receptors do not oligomerize in cells, Sci Rep, 5: 0166.

Lecru L, Desterke C, Grassin-Delyle S, Chatziantoniou C, Vandermeersch S, Devocelle A, Vernochet A, Ivanovski N, Ledent C, Ferlicot S, Dalia M, Saïd M, Beaudreuil S, Charpentier B, Vazquez A, Giron-Michel J, Azzarone B, Durrbach A, François H (2015). Cannabinoid receptor 1 is a major mediator of renal fibrosis. Kidney Int. 88: 72-84.

Lichtenstein L, Serhan N, Espinosa-Delgado S, Fabre A, Annema W, Tietge UJ, Robaye B, Boeynaems JM, Laffargue M, Perret B, Martinez LO (2015). Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport. Cardiovasc Res 106: 314-323.

Lismont E, Vleugels R, Marchal E, Badisco L, Van Wielendaele P, Lenaerts C, Zels S, Tobe SS, Vanden Broeck J, Verlinden H (2015). Molecular cloning and characterization of the allatotropin precursor and receptor in the desert locust, Schistocerca gregaria. Front Neurosci 9 : 84 (p1-14).

Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda MA, Gonçalvès D, Cerezo M, Marchetti S, Rocchi S, Droin N, Cluzeau T, Robert G, Luciano F, Robaye B, Foretz M, Viollet B, Legros L, Solary E, Auberger P, Jacquel A (2015). The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy 11: 1114-1129.

Parmentier M (2015). CCR5 and HIV Infection, a View from Brussels. Front Immunol 6: 295.

Parmentier M (2015). GPCRs: Heterodimer-specific signaling. Nat Chem Biol 11: 244-245.

Pradhan I, Ledent C, Mustafa SJ, Morisseau C, Nayeem MA (2015). High salt diet modulates vascular response in A2AAR+/+ and A2AAR-/- mice: role of sEH, PPARγ, and K ATP channels. Mol Cell Biochem 404: 87-96.

Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P (2015). Cytokines in systemic juvenile idiopatic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-g. Rheumatology 54: 1507-1517.

Relvas LJ, Makhoul M, Dewispelaere R, Caspers L, Communi D, Boeynaems JM, Robaye B, Bruyns C, Willermain F (2015). P2Y2R deficiency attenuates experimental autoimmune uveitis development. PLoS One 10: e0116518.

Ring S, Pushkarevskaya A, Schild H, Probst HC, Jendrossek V, Wirsdörfer F, Ledent C, Robson SC, Enk AH, Mahnke K (2015). Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway. J Immunol 194: 3735-44.

Seeger P, Musso T, Sozzani S (2015). The TGF-β superfamily in dendritic cell biology. Cytokine Growth Factor Rev 26: 647-657.

Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S (2015). Propagation of conformational changes during μ-opioid receptor activation. Nature 524: 375-378.

Sozzani S, Del Prete A (2015). Chemokines as relay signals in human dendritic cell migration: serum amyloid A kicks off chemotaxis. Eur J Immunol 45: 40-43.

Sozzani S, Del Prete A, Bonecchi R, Locati M (2015). Chemokines as effector and target molecules in vascular biology. Cardiovasc Res 107: 364-372.

Van Hiel MB, Vandersmissen HP, Proost P, Vanden Broeck J (2015). Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster. Peptides 68: 83-90.

Van Raemdonck K, Van den Steen P, Liekens S, Van Damme J, Struyf S (2015). CXCR3 ligands in disease and therapy. Cytokine & Growth Factor Reviews 26: 311-327.

Vandermeulen E, Verleden S, Ruttens D, Moelants E, Mortier A, Somers J, Bellon H, Piloni D, Dupont L, Van Raemdonck D, Proost P, Schols D, Vos R, Verleden G, Vanaudenaerde B (2015). BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance. Transplant Immunol 33: 37-44

Vandooren J, Born B, Solomonov I, Zajac E, Saldova R, Senske M, Ugarte-Berzal E, Martens E, Van den Steen PE, Van Damme J, Garcia-Pardo A, Froeyen M, Deryugina EI, Quigley JP, Moestrup SK, Rudd PM, Sagi I, Opdenakker G (2015). Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1. Biochem J 465: 259-270.

Vandooren J, Van Damme J, Opdenakker G (2015). On the structure and functions of gelatinase B/matrix metalloproteinase-9 in neuroinflammation. In: Alexander Dityatev, Wehrle-Haller B, Pitkänen A (editors). Progress in Brain Research, Vol. 214, Amsterdam: Elsevier, 2014. Pp. 193-206.

Verleden SE, Ruttens D, Vos R, Vandermeulen E, Moelants E, Mortier A, Van Raemdonck DE, Proost P, Schols D, Verleden GM, Vanaudenaerde BM (2015). Differential cytokine, chemokine and growth factor expression in phenotypes of chronic lung allograft dysfunction. Transplantation 99, 86-93.

Verlinden H, Gijbels M, Lismont E, Lenaerts C, Vanden Broeck J, Marchal E (2015). The pleiotropic allatoregulatory neuropeptides allatotropin and allatostatin and their receptors: a mini-review. J Insect Physiol 80: 2-14.

Verlinden H, Vleugels R, Verdonck R, Urlacher E, Vanden Broeck J, Mercer A (2015). Pharmacological and Signaling Properties of a D2-like Dopamine Receptor (Dop3) in Tribolium castaneum. Insect Biochem Mol Biol 56: 9-20.

Vleugels R, Verlinden H, Vanden Broeck J (2015). Serotonin, serotonin receptors and their actions in insects. Neurotransmitter 2, e314 (p1-14).

Zels S, Dillen S, Crabbé K, Spit J, Nachman RJ, Vanden Broeck J (2015). Sulfakinin is an important regulator of digestive processes in the migratory locust, Locusta migratoria. Insect Biochem Mol Biol 61: 8-16.

Zhou Z, Rajamani U, Labazi H, Tilley SL, Ledent C, Teng B, Mustafa SJ (2015). Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts. Purinergic Signal 11: 263-73.



Andersson O, Badisco L, Hansen A, Hansen S, Hellman K, Nielsen P, Olsen L, Verdonck R, Abbott N, Vanden Broeck J, Andersson G (2014). Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model. Pharmacol Res Perspect 2: e00050 (p1-12).

Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M (2014). New nomenclature for atypical chemokine receptors. Nat Immunol 15: 207-8.

Balasubramanian R, Robaye B, Boeynaems JM, Jacobson KA (2014). Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. PLoS One 9: e116203.

Bosisio D, Salvi V, Gagliostro V, Sozzani S (2014). Angiogenic and antiangiogenic chemokines. Chem Immunol Allergy 99: 89-104.

Burnstock G, Boeynaems JM (2014). Purinergic signalling and immune cells. Purinergic Signal 10: 529-564.

Conrad M, Schothorst J, Kankipati HN, Van Zeebroeck G, Rubio-Texeira M, Thevelein JM (2014). Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 38: 254-299.

Del Prete A, Salvi V, Sozzani S (2014). Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm 2014: 425068.

Dillen S, Verdonck R, Zels S, Van Wielendaele P, Vanden Broeck J (2014). Identification of the short neuropeptide F precursor in the desert locust: Evidence for an inhibitory role of sNPF in the control of feeding. Peptides 53: 134-139.

Fernández-Dueñas V, Gómez-Soler M, López-Cano M, Taura JJ, Ledent C, Watanabe M, Jacobson KA, Vilardaga JP, Ciruela F (2014). Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. ACS Chem Biol 9:2496-2501.

Filippi I, Morena E, Aldinucci C, Carraro F, Sozzani S, Naldini A (2014). Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway. J Cell Physiol 229: 2067-2076.

Garcia MI, Vassart G (2014). Identification of progenitors of the foetal intestinal epithelium. Med Sci (Paris) 30: 353-355.

Goeminne PC, Vandooren J, Moelants EA, Decraene A, Rabaey E, Pauwels A, Seys S, Opdenakker G, Proost P, Dupont LJ (2014) The Sputum Colour Chart as a predictor of lung inflammation, proteolysis and damage in non-cystic fibrosis bronchiectasis: A case-control analysis. Respirology 19: 203-210.

Gonzalvo-Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, Bierschenk S, Sperandio M, Vecchi A, Sozzani S (2014). Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol 192: 2366-73.

Gouwy M, Struyf S, Leutenez L, Pörtner N, Sozzani S, Van Damme J (2014). Chemokines and other GPCR ligands synergize in receptor-mediated migration of monocyte-derived immature and mature dendritic cells. Immunobiology 219: 218-229.

Grob F, Deladoëy J, Legault L, Spigelblatt L, Fournier A, Vassart G, Van Vliet G (2014). Autonomous adenomas caused by somatic mutations of the thyroid-stimulating hormone receptor in children. Horm Res Paediatr 81: 73-79

Huang J, Marchal E, Hult E, Zels S, Vanden Broeck J, Tobe S (2014). Mode of action of allatostatins in the regulation of juvenile hormone biosynthesis in the cockroach, Diploptera punctata. Insect Biochem Mol Biol 54: 61-68.

Li S, Pettersson US, Hoorelbeke B, Kolaczkowska E, Schelfhout K, Martens E, Kubes P, Van Damme J, Phillipson M, Opdenakker G (2014). Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo. PLOS One 9: e104107.

Moelants EA, Loozen G, Mortier A, Martens E, Opdenakker G, Mizgalska D, Szmigielski B, Potempa J, Van Damme J, Teughels W, Proost P (2014). Citrullination and proteolytic processing of chemokines by Porphyromonas gingvalis. Infection and Immunity 82: 2511-19.

Pardon E, Laeremans T, Triest S, Rasmussen SG, Wohlkönig A, Ruf A, Muyldermans S, Hol WG, Kobilka BK, Steyaert J (2014) A general protocol for the generation of Nanobodies for structural biology. Nat Protoc 9: 674-693.

Peeters K, Thevelein JM (2014). Glucose sensing and signal transduction. pp. 21-56. In: 'Molecular Mechanisms in Yeast Carbon Metabolism', Eds. Concetta Compagno and Jure Piskur, Springer.

Pradhan I, Zeldin DC, Ledent C, Mustafa JS, Falck JR, Nayeem MA (2014). High salt diet exacerbates vascular contraction in the absence of adenosine A2a receptor. J Cardiovasc Pharmacol 63: 385-394.

Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D (2014). Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J 28: 117-130.

Santos D, Vanden Broeck J, Wynant N (2014). Systemic RNA interference in locusts: reverse genetics and possibilities for locust pest control. Current Opinion in Insect Science 6: 9–14.

Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S (2014). Activin A as a mediator of NK-dendritic cell functional interactions. J Immunol 192: 1241-1248.

Sozzani S, Abbracchio MP, Annese V, Danese S, De Pità O, De Sarro G, Maione S, Olivieri I, Parodi A, Sarzi-Puttini P (2014). Chronic inflammatory diseases: do immunological patterns drive the choice of biotechnology drugs? A critical review. Autoimmunity 47: 287-306.

Spit J, Zels S, Dillen S, Holtof M, Wynant N, Vanden Broeck J (2014). Effects of different dietary conditions on the expression of trypsin- and chymotrypsin-like protease genes in the digestive system of the migratory locust, Locusta migratoria. Insect Biochem Mol Biol 48: 100-109.

Staus DP, Wingler LM, Strachan RT, Rasmussen SGF, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ (2014) Regulation of b2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharm 85: 472-481.

Traversari C, Sozzani S, Steffensen KR, Russo V (2014). LXR-dependent and -independent effects of oxysterols on immunity and tumor growth. Eur J Immunol 44: 1896-1903.

Triest S, Wohlkönig A, Pardon E, Steyaert J (2014). Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody. Acta Crystallogr F Struct Biol Commun 70: 1504-1507.

Valcamonica E, Chighizola CB, Comi D, De Lucia O, Pisoni L, Murgo A, Salvi V, Sozzani S, Meroni PL (2014). Levels of chemerin and interleukin 8 in the synovial fluid of patients with inflammatory arthritides and osteoarthritis. Clin Exp Rheumatol 32: 243-250.

Van Raemdonck K, Berghmans N, Vanheule V, Bugatti A, Proost P, Opdenakker G, Presta M, Van Damme J, Struyf S. (2014). Angiostatic, tumor inflammatory and anti-tumor effects of CXCL4(47-70) and CXCL4L1(47-70) in an EGF-dependent breast cancer model. Oncotarget 5: 10916-10933.

Van Raemdonck K, Gouwy M, Lepers SA, Van Damme J, Struyf S (2014). CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase. Angiogenesis 17: 631-640.

Van Raemdonck K, Proost P, Van Damme J, Struyf S. (2014) PF4 (platelet factor 4). Atlas Genet Cytogenet Oncol Haematol, URL: http://AtlasGeneticsOncology.org/Genes/PF4ID41693ch4q13.html

Van Zeebroeck G, Rubio-Texeira M, Schothorst J, Thevelein JM  (2014). Specific analogues uncouple transport, signalling, oligo-ubiquitination and endocytosis in the yeast Gap1 amino acid transceptor. Mol Microbiol 93: 213-233.

Vandersmissen H, Van Hiel B, Van Loy T, Vleugels R, Vanden Broeck J (2014). Silencing D. melanogaster Igr 1 impairs transition from larval to pupal stage. Gen Comp Endocrinol 209: 135-147.

Vassart G, Kleinau G. TSH Receptor Mutations and Diseases (2014). In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext. South Dartmouth.

Verlinden H, Vleugels R, Zels S, Dillen S, Lenaerts C, Crabbé K, Spit J, Vanden Broeck J (2014). Receptors for neuronal or endocrine signaling molecules as potential targets for the control of insect pests. Adv Insect Physiol 46: 167-303.

Vleugels R, Lenaerts C, Vanden Broeck J, Verlinden H (2014). Signalling properties and pharmacology of a 5-HT7-type serotonin receptor from Tribolium castaneum. Insect Mol Biol 23: 230-243.

Vos R, Verleden SE, Ruttens D, Vandermeulen E, Bellon H, Neyrinck A, Van Raemdonck DE, Yserbyt J, Dupont LJ, Verbeken EK, Moelants E, Mortier A, Proost P, Schols D, Cox B, Verleden GM, Vanaudenaerde BM (2014). Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation. Am J Transplantation 14: 2736-2748.

Voss U, Turesson MF, Robaye B, Boeynaems JM, Olde B, Erlinge D, Ekblad E (2014). The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Purinergic Signal 10: 455-464.

Wang N, Robaye B, Gossiel F, Boeynaems JM, Gartland A (2014). The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development. FASEB J 28: 2249-2259.

Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, Christesen HT, Schuit F, Proost P, Masini M, Marchetti P, Eizirik DL, Overbergh L, Mathieu C (2014). Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans. Endocrinology 155: 736-47.

Wynant N, Duressa T, Santos D, Van Duppen J, Proost P, Huybrechts R, Vanden Broeck J (2014). Lipophorins can adhere to dsRNA, bacteria and fungi present in the hemolymph of the desert locust: a role as general scavenger for pathogens in the open body cavity. J Insect Physiol 64: 7-13.

Zanos P, Wright SR, Georgiou P, Yoo JH, Ledent C, Hourani SM, Kitchen I, Winsky-Sommerer R, Bailey A (2014). Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent mechanism. Pharmacol Biochem Behav 119: 72-79.

Zels S, Verlinden H, Dillen S, Vleugels R, Nachman R, Vanden Broeck J (2014). Signaling properties and pharmacological analysis of two sulfakinin receptors from the red flour beetle, Tribolium castaneum. PLoS One 9, e94502 (p1-11).

Zhou X, Teng B, Tilley S, Ledent C, Mustafa SJ (2014). Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts. Am J Physiol Heart Circ Physiol 307: H1046-1055.



Abbracchio MP, Boeynaems JM, Cattaneo M, Virgilio FD, Illes P, Inoue K, Jacobson KA, Teresa Miras-Portugal M, Ralevic V, Robson SC, Verkhratsky A, Zimmermann H (2013). Reply to: 'The discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis'. Acta Physiol (Oxf) 208: 139-40.

Audsley N, Vandersmissen H, Weaver R, Dani P, Matthews J, Down R, Vuerinckx K, Kim Y, Vanden Broeck J (2013). Characterisation and tissue distribution of the PISCF allatostatin receptor in the red flour beetle, Tribolium castaneum. Insect Biochem Mol Biol, 43: 65-74.

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A (2013). International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev 66: 1-79.

Badisco L, Van Wielendaele P, Vanden Broeck J (2013). Eat to reproduce: a key role for the insulin signaling pathway in adult insects. Frontiers in Physiology 4: 1-16.

Besnard AG, Struyf S, Guabiraba R, Fauconnier L, Rouxel N, Proost P, Uyttenhove C, Van Snick J, Couillin I, Ryffel B  (2013). CXCL6 antibody neutralization prevents lung inflammation in fibrosis in mice in the bleomycin model. J Leukoc Biol 94: 1317-1323.

Biver G, Wang N, Gartland A, Orriss I, Arnett TR, Boeynaems JM, Robaye B (2013). Role of the P2Y13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes. Stem Cells 31: 2747-2758.

Blondin L, Badisco L, Pagès C, Foucart A, Risterucci AM, Bazelet C, Vanden Broeck J, Song H, Ould Ely S, Chapuis MP (2013). Characterization and comparison of microsatellite markers derived from genomic and expressed libraries for the desert locust. J Applied Entomology 137: 673-683.

Cacciola G, Chioccarelli T, Altucci L, Ledent C, Mason JI, Fasano S, Pierantoni R, Cobellis G (2013). Low 17beta-estradiol levels in CNR1 knock-out mice affect spermatid chromatin remodeling by interfering with chromatin reorganization. Biol Reprod 88:152.

Castanares-Zapatero D, Bouleti C, Sommereyns C, Gerber B, Lecut C, Mathivet T, Horckmans M, Communi D, Foretz M, Vanoverschelde JL, Germain S, Bertrand L, Laterre PF, Oury C, Viollet B, Horman S, Beauloye C (2013). Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform. Crit Care Med. 41: e411-422.

De Buck M, Gouwy M, Proost P, Struyf S, Van Damme J (2013). Identification and characterization of MIP-1α/CCL3 isoform 2 from bovine serum as a potent monocyte/dendritic cell chemoattractant. Biochem Pharmacol 85: 789-797.

De Poorter C, Baertsoen K, Lannoy V, Parmentier M, Springael JY (2013). Consequences of ChemR23 heteromerization with the chemokine receptors CXCR4 and CCR7. PLoS One 8: e58075.

Del Prete A, Bonecchi R, Vecchi A, Mantovani A, Sozzani S (2013). CCRL2, a fringe member of the atypical chemoattractant receptor family. Eur J Immunol 43: 1418-1422.

Denis CJ, Deiteren K, Hendriks D, Proost P, Lambeir AM (2013). Carboxypeptidase M in apoptosis, adipogenesis and cancer. Clin Chim Acta 16: 306-16.

Dillen S, Zels S, Verlinden H, Spit J, Van Wielendaele P, Vanden Broeck J (2013). Functional characterization of the short Neuropeptide F receptor in the desert locust, Schistocerca gregaria. PLoS One, 8, e53604 (p.1-9).

Förster R, Sozzani S (2013). Emerging aspects of leukocyte migration. Eur J Immunol 43: 1404-1406.

Guenther F, Herr N, Mauler M, Witsch T, Roming F, Hein L, Boeynaems JM, Robaye B, Idzko M, Bode C, von Zur Muhlen C, Duerschmied D (2013). Contrast ultrasound for the quantification of deep vein thrombosis in living mice - effects of enoxaparin and P2Y12 receptor inhibition. J Thromb Haemost 11: 1154-1162.

Hadad I, Veithen A, Springael JY, Sotiropoulou PA, Mendes Da Costa A, Miot F, Naeije R, De Deken X, Entee KM (2013). Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes. PLoS One 8:e56007.

Hua X, Chason KD, Jania C, Acosta T, Ledent C, Tilley SL (2013). Gs-coupled adenosine receptors differentially limit antigen-induced mast cell activation. J Pharmacol Exp Ther 344: 426-435.

Hua X, Naselsky WC, Bennett WD, Ledent C, Senior BA, Tilley SL (2013). Adenosine increases nasal mucociliary clearance rate in mice through A2A and A2B adenosine receptors. Laryngoscope 123 :306-310.

Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M (2013). Conformational biosensors reveal GPCR signalling from endosomes. Nature 495: 534-538. News & views: Lohse MJ, Calebiro D (2013) Cell biology: Receptor signals come in waves. Nature 495: 457-458.

Köles L, Garção P, Zádori ZS, Ferreira SG, Pinheiro BS, da Silva-Santos CS, Ledent C, Köfalvi A (2013). Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain. Brain Res Bull 97: 126-135.

Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK (2013). Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504: 101-106.

Lavie M, Struyf S, Stroh-Dege A, Rommelaere J, Van Damme J, Dinsart C (2013) Capacity of wild-type and chemokine-armed parvovirus H-1PV for inhibiting neo-angiogenesis. Virology 447: 221-232.

Lee D, Vanden Broeck J, Lange A (2013). Identification and expression of the CCAP receptor in the Chagas’ disease vector, Rhodnius prolixus, and its involvement in cardiac control. PLoS One 8: e68897 (p.1-11).

Liao Y, Bin J, Luo T, Zhao H, Ledent C, Asakura M, Xu D, Takashima S, Kitakaze M (2013). CB1 cannabinoid receptor deficiency promotes cardiac remodeling induced by pressure overload in mice. Int J Cardiol 167:1936-1944.

Lichtenstein L, Serhan N, Annema W, Combes G, Robaye B, Boeynaems JM, Perret B, Tietge UJ, Laffargue M, Martinez LO (2013). Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport. Nutr Metab (Lond) 10:67.

Lorenzi L, Tabellini G, Vermi W, Moratto D, Porta F, Notarangelo LD, Patrizi O, Sozzani S, de Saint Basile G, Latour S, Pace D, Lonardi S, Facchetti F, Badolato R, Parolini S (2013). Occurrence of nodular lymphocyte-predominant Hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects. PLoS One 8: e80131.

Maina V, Marrella V, Mantero S, Cassani B, Fontana E, Anselmo A, Del Prete A, Sozzani S, Vezzoni P, Poliani PL, Villa A (2013). Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol 94: 1221-1230.

Máthé D, Horváth I, Szigeti K, Donohue SR, Pike VW, Jia Z, Ledent C, Palkovits M, Freund TF, Halldin C, Gulyás B (2013). In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse. Brain Res Bull 91: 46-51.

Metaxas A, Al-Hasani R, Farshim P, Tubby K, Berwick A, Ledent C, Hourani S, Kitchen I, Bailey A (2013). Genetic deletion of the adenosine A2A receptor prevents nicotine-induced upregulation of α7, but not α4β2* nicotinic acetylcholine receptor binding in the brain. Neuropharmacology 71: 228-236.

Moelants E, Mortier A, Grauwen K, Ronsse I, Van Damme J, Proost P (2013). Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines. Cytokine 61: 161-167.

Moelants E, Mortier A, Van Damme J, Proost P (2013). In vivo regulation of chemokine activity by post-translational modification. Immunol. Cell Biol, 91: 402-407.

Moelants EA, Mortier A, Van Damme J, Proost. P (2013). Regulation of TNF-α with a focus on rheumatoid arthritis. Immunol. Cell Biol. 91: 393-401.

Mustata RC, Vasile G, Fernandez-Vallone V, Strollo S, Lefort A, Libert F, Monteyne D, Pérez-Morga D, Vassart G, Garcia MI (2013). Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium. Cell Rep 5: 421-432.

Nawaz M, Van Raemdonck K, Mohammad G, Kangave D, Van Damme J, Abu-El Asrar A, Struyf S (2013). Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy. Exp Eye Res 109: 67-76.

Pardo M, López-Cruz L, Valverde O, Ledent C, Baqi Y, Müller CE, Salamone JD, Correa M (2013). Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice. Behav Brain Res 247: 217-26.

Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D (2013). Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS One 8: e82867.

Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V (2013). The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med 210: 1711-1728.

Reichelt ME, Ashton KJ, Tan XL, Mustafa SJ, Ledent C, Delbridge LM, Hofmann PA, Headrick JP, Morrison RR (2013). The adenosine A2A receptor – Myocardial protectant and coronary target in endotoxemia. Int J Cardiol 166: 672-680.

Rouger L, Denis GR, Luangsay S, Parmentier M (2013). ChemR23 knockout mice display mild obesity but no deficit in adipocyte differentiation. J Endocrinol 219: 279-289.

Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, Bosisio D, Sozzani S, Musso T (2013). Dual regulation of osteopontin production by TLR stimulation in dendritic cells. J Leukoc Biol 94:147-158.

Schothorst J, Kankipati HN, Conrad M, Samyn DR, Van Zeebroeck G, Popova Y, Rubio-Texeira M, Persson BL, Thevelein JM (2013). Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters. Curr Genet 59: 197-206.

Sharifi-Sanjani M, Zhou X, Asano S, Tilley S, Ledent C, Teng B, Dick GM, Mustafa SJ (2013). Interactions between A2A adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. Am J Physiol Heart Circ Physiol 304: H1294-1301.

Swevers L, Vanden Broeck J, Smagghe G (2013). The possible impact of persistent virus infection on the function of the RNAi machinery in insects: a hypothesis. Frontiers in Physiology 4: 1-15.

Teng B, Fil D, Tilley SL, Ledent C, Krahn T, Mustafa SJ (2013). Functional and RNA expression profile of adenosine receptor subtypes in mouse mesenteric arteries. J Cardiovasc Pharmacol 61 :70-76.

Tobback J, Verlinden H, Vuerinckx K, Vleugels R, Vanden Broeck J, Huybrechts R (2013). Developmental- and food-dependent foraging transcript in the desert locust. Insect Science 20: 679-688.

van Hoef V, Breugelmans B, Spit J, Simonet G, Zels S, Vanden Broeck J (2013). Phylogenetic distribution of protease inhibitors of the Kazal-family within the Arthropoda. Peptides 41: 59-65.

Van Wielendaele P, Badisco L, Vanden Broeck J (2013). Neuropeptidergic regulation of reproduction in insects. Gen Comp Endocrinol 188: 23-34.

Van Wielendaele P, Wynant N, Dillen S, Badisco L, Marchal E, Vanden Broeck J (2013). In vivo effect of Neuropeptide F on ecdysteroidogenesis in adult female desert locusts (Schistocerca gregaria). J Insect Physiol 59: 624-630.

Van Wielendaele P, Wynant N, Dillen S, Zels S, Badisco L, Vanden Broeck J (2013). Neuropeptide F regulates male reproductive processes in the desert locust, Schistocerca gregaria. Insect Biochem Mol Biol 43: 252-259.

Van Wielendaele, P., Dillen, S., Zels, S., Badisco, L., Vanden Broeck, J. (2013). Regulation of feeding by Neuropeptide F in the desert locust, Schistocerca gregaria. Insect Biochem Mol Biol 43: 102-114.

Vandersmissen H, Nachman R, Vanden Broeck J (2013). Sex peptides and MIPs can activate the same G protein-coupled receptor. Gen Comp Endocrinol 188: 137-143.

Verlinden H, Lismont E, Bil M, Urlacher E, Mercer A, Vanden Broeck J, Huybrechts R (2013). Characterisation of a functional allatotropin receptor in the bumblebee, Bombus terrestris (Hymenoptera, Apidae). General and Comparative Endocrinology 193: 193-200.

Vermi W, Giurisato E, Lonardi S, Balzarini P, Rossi E, Medicina D, Bosisio D, Sozzani S, Pellegrini W, Doglioni C, Marchetti A, Rossi G, Pileri S, Facchetti F (2013). Ligand-dependent activation of EGFR in follicular dendritic cells sarcoma is sustained by local production of cognate ligands. Clin Cancer Res 19: 5027-5038.

Vleugels R, Lenaerts C, Baumann A, Vanden Broeck J, Verlinden H (2013). Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum. PLoS One 8, e65052 (p.1-10).

Wang N, Rumney RM, Yang L, Robaye B, Boeynaems JM, Skerry TM, Gartland A (2013). The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading. J Bone Miner Res 28: 1446-1456.



Abu El-Asrar A, Struyf S, Kangave D, Al-Obeidan S, Opdenakker G, Geboes K, Van Damme J (2012). Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. Cytokine 59: 377-381.

Ayata CK, Ganal SC, Hockenjos B, Willim K, Vieira RP, Grimm M, Robaye B, Boeynaems JM, Di Virgilio F, Pellegatti P, Diefenbach A, Idzko M, Hasselblatt P (2012). Purinergic P2Y2 receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterology 143: 1620-1629.

Bondue B, De Henau O, Luangsay S, Devosse T, de Nadaï P, Springael JY, Parmentier M, Vosters O (2012). The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLOS One 7: e40043.

Brown RM, Duncan JR, Stagnitti MR, Ledent C, Lawrence AJ (2012). mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine. Int J Neuropsychopharmacol 15: 995-1001.

Caers J, Verlinden H, Zels S, Vandersmissen HP, Vuerinckx K, Schoofs L (2012). More than two decades of research on insect neuropeptide GPCRs: an overview. Front Endocrinol 3: 151.

Carlino C, Trotta E, Stabile H, Morrone S, Bulla R, Soriani A, Iannitto ML, Agostinis C, Mocci C, Minozzi M, Aragona C, Perniola G, Tedesco F, Sozzani S, Santoni A, Gismondi A (2012). Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy. J Clin Endocrinol Metab 97: 3603-3612.

Castermans D, Somers I, Kriel J, Louwet W, Wera S, Versele M, Janssens V and Thevelein JM (2012). Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Research 22: 1058-1077.

De Sutter J, Van de Veire N, Struyf S, Philippé J, De Buyzere M, Van Damme J (2012). PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function. Plos One 7: e31343.

Dempe S, Lavie M, Struyf S, Bhat R, Verbeke H, Paschek S, Berghmans N, Geibig R, Rommelaere J, Van Damme J, Dinsart C (2012). Antitumoral activity of parvovirus-mediated IL-2 and MCP-3/CCL7 delivery into human pancreatic cancer: implication of leucocyte recruitment. Cancer Immunol Immunother 61: 2113-2123.

Denis C, Deiteren K, Mortier A, Tounsi A, Fransen E, Proost P, Renauld JC, Lambeir AM (2012). C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity. PLoS One 7: e34199.

Derks NM, Pintér O, Zuure W, Ledent C, Watanabe M, Molnár CS, Wei Y, Roubos EW, Wu S, Hrabovszky E, Zelena D, Kozicz T (2012). Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress. J Neuroendocrinol 24: 1447-1461.

Ferreira SG, Teixeira FM, Garção P, Agostinho P, Ledent C, Cortes L, Mackie K, Köfalvi A (2012). Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. Neurochem Int 61: 219-226.

Gouwy M, Schiraldi M, Struyf S, Van Damme J, Uguccioni M (2012). Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response. Immunol Lett 145: 10-14.

Haesendonckx S, Tudisca V, Voordeckers K, Moreno S, Thevelein JM and Portela P (2012). Activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae. Biochem J 448 : 307-320.

Horckmans M, Léon-Gómez E, Robaye B, Balligand JL, Boeynaems JM, Dessy C, Communi D (2012). Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise. Am J Physiol Heart Circ Physiol 303: H835-843.

Horckmans M, Robaye B, Léon-Gόmez E, Lantz N, Unger P, Dol-Gleizes F, Clouet S, Cammarata D, Schaeffer P, Savi P, Gachet C, Balligand JL, Dessy C, Boeynaems JM, Communi D (2012). P2Y4 nucleotide receptor: a novel actor in post-natal cardiac development. Angiogenesis 15: 349-360.

Kimpe M, Voordeckers K, Thevelein JM and Van Zeebroeck G (2012). Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2alpha system. Biochem Biophys Res Commun 419 : 89-94.

Lange A, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I (2012). The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, Rhodnius prolixus. Front Neurosci 6: 98.

Langer I (2012). Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies. Front Endocrinol (Lausanne) 3:129.

Liao Y, Bin J, Asakura M, Xuan W, Chen B, Huang Q, Xu D, Ledent C, Takashima S, Kitakaze M (2012). Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload in mice. Eur Heart J 33: 3124-3133.

Marchal E, Verlinden H, Badisco L, Van Wielendaele P, Vanden Broeck J (2012). RNAi-mediated knockdown of Shade negatively affects ecdysone-20-hydroxylation in the desert locust, Schistocerca gregaria. J Insect Physiol 58: 890-896.

Moelants E, Mortier A, Van Damme J, Proost, Loos T (2012). Peptidylarginine deiminases: physiological function, interaction with chemokines and role in pathology. Drug Discovery Today: Technologies, e261-e280.

Mortier A, Van Damme J, Proost P (2012). Overview of the mechanisms regulating chemokine activity and availability. Immunol Lett 145: 2-9.

Olivier P, Simoneau-Roy J, Francoeur D, Sartelet H, Parma J, Vassart G, Van Vliet G (2012). Leydig cell tumors in children: contrasting clinical, hormonal, anatomical, and molecular characteristics in boys and girls. J Pediatr 161:1147-52.

Ott S, Verlinden H, Rogers S, Brighton S, Quah P, Vleugels R, Verdonck R, Vanden Broeck J (2012). Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust. Proc Natl Acad Sci USA 109: E381-E387.

Pardo M, Lopez-Cruz L, Valverde O, Ledent C, Baqi Y, Müller CE, Salamone JD, Correa M (2012). Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice. Neuropharmacology 62: 2068-2077.

Parmentier M (2012). Shedding light on G protein-coupled receptor signaling. Nat Methods 9: 965-966.

Ponnoth DS, Nayeem MA, Tilley SL, Ledent C, Jamal Mustafa S (2012). CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels. Am J Physiol Regul Integr Comp Physiol 303: R1003-1010.

Rubio-Texeira M, Van Zeebroeck G and Thevelein JM (2012). Peptides induce persistent signaling from endosomes by a nutrient transceptor. Nature Chemical Biology 8: 400-408.

Samyn DR, Ruiz-Pávon L, Popova Y, Andersson MR, Thevelein JM and Persson BL (2012). Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H+ transceptor and its effect on signaling to the PKA and PHO pathways. Biochem J 445: 413-422.

Schepers W, Van Zeebroeck G, Pinkse M, Verhaert P and Thevelein JM (2012). In vivo phosphorylation of Ser21 and Ser83 during nutrient-induced activation of the yeast protein kinase A (PKA) target trehalase. J Biol Chem 287:4 4130-44142.

Spit J, Badisco L, Verlinden H, Van Wielendaele P, Zels S, Dillen S, Vanden Broeck J (2012). Peptidergic control of food intake and digestion in insects. Canadian Journal of Zoology 90: 489-506.

Spit J, Breugelmans B, van Hoef V, Simonet G, Zels S, Vanden Broeck J (2012). Growth-inhibition effects of pacifastin-like peptides on a pest insect: The desert locust, Schistocerca gregaria. Peptides 34: 251-257.

Tourino C, Valjent E, Ruiz-Medina J, Herve D, Ledent C, Valverde O (2012). The orphan receptor GPR3 modulates the early phases of cocaine reinforcement. Br J Pharmacol 167: 892-904.

Uesugi A, Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Robaye B, Boeynaems JM, Inoue K (2012). Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis. Glia 60: 1094-1105.

Van Hiel M, Vandersmissen H, Van Loy T, Vanden Broeck J (2012). An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype. Peptides 34: 193-200.

Van Wielendaele P, Dillen S, Marchal E, Badisco L, Vanden Broeck, J. (2012). CRF-like diuretic hormone negatively affects both feeding and reproduction in the desert locust, Schistocerca gregaria. PLoS One 7: e31425.

Vandamme J, Castermans D and Thevelein JM (2012). Molecular mechanisms of feedback-inhibition of protein kInase A on intracellular cAMP accumulation. Cellular Signaling 24: 1610-1618.

Vandergheynst F, Pradier O, Beukinga I, Kornreich A, Vassart G, Decaux G (2012). Lack of responsiveness to 1-desamino-D arginin vasopressin (desmopressin) in male patients with nephrogenic syndrome of inappropriate antidiuresis: from bench to bedside. Eur J Clin Invest 42: 254-259.

Vanderstocken G, Van de Paar E, Robaye B, di Pietrantonio L, Bondue B, Boeynaems JM, Desmecht D, Communi D (2012). Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. PLoS One 7: e50385.

Verbeke H, Geboes K, Van Damme J, Struyf S (2012). The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer. Biochim Biophys Acta 1825: 117-129.

Wells L, Opacka-Juffry J, Fisher D, Ledent C, Hourani S, Kitchen I (2012). In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A2A receptor knockout mice. Synapse 66: 383-390.

Wynant N, Verlinden H, Breugelmans B, Simonet G, Vanden Broeck, J (2012). Tissue-dependence and sensitivity of the systemic RNA interference response in the desert locust, Schistocerca gregaria. Insect Biochem. Mol Biol 42: 911-917.

Zoenen M, Urizar E, Swillens S, Vassart G, Costagliola S (2012). Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers. Nat Commun 3: 1007.

Home  -  Partners  -  Program overview  -  Publications  -  Conferences & meetings  -  Open positions  -  Intranet  -  Links  -  Contacts

Last changed: June 3, 2016.