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recherches menées au labo


Une présentation de la brochure est disponible dans le catalogue des publications de l’ULB.

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estimation et contrôle biologique
du risque de contamination humaine à Bruxelles par
les agents pathogènes de campagnols.
Les hantavirus,
dont les rongeurs sont les réservoirs, provoquent chez
l'homme des infections potentiellement mortelles. Ils semblent
toutefois rester sans symptômes chez leur espèce
réservoir. Différents sérotypes de ces
virus sont présents de l'Asie aux Amériques. En Europe, les
campagnols roussâtres, Myodes glareolus,
portent l'hantavirus de type Puumala et transmettent à
l'homme une fièvre hémorragique à syndrome
rénal (la néphropathie épidémique). Cette maladie
s'attrape très probablement par inhalation de poussières
ou d'aérosols contaminés par les déjections
de campagnols. Elle est rarement mortelle. Le mulot sylvestre,
espèce sympatrique du campagnol roussâtre, ne porte
habituellement pas d'hantavirus.
Ce projet
a pour but de :
(1) comprendre les mécanismes
des dynamiques temporelle et spatiale des infections
par hantavirus dans différentes populations de
rongeurs,
(2) comparer l'organisation spatiale
des animaux sains et infectés, et
(3) tester l'influence d'odeurs
de prédateurs sur les déplacements
des campagnols lors de leur recherche de nourriture.
Les densités
des campagnols et la présence d'hantavirus (la séroprévalence)
sont étudiées dans la Forêt de Soignes
(au sud de Bruxelles). Par des captures non mortelles, ce
travail suit les variations locales d'organisation spatiale
et de répartition des individus sains et infectés.
En outre, cette étude teste
au laboratoire la façon dont la présence
d'odeurs de prédateurs modifie les mouvements des campagnols
au sein d'un réseau régulier de voies
de déplacement (grâce au logiciel Ethovision).
La clef d'un contrôle biologique des mouvements des
populations de campagnols pourrait résider dans l'utilisation
mesurée de telles odeurs de prédateurs.
Un tel contrôle pourrait limiter le risque d'infection
et les dégâts agricoles dus à certaines espèces
de rongeurs.
Suite
à cette recherche, une brochure
pour le grand public sur les maladies transmises par les animaux est diffusée (aussi en néerlandais).
Une plaquette informative sur les hantavirus est aussi disponible sur le site
de l'Institut scientifique de Santé publique, qui distribue
la brochure en version imprimée. Les brochures imprimées
sont également disponibles auprès de l'Institut des Sciences
naturelles de Belgique et de certaines communes bruxelloises (Etterbeek,
Ixelles, Saint-Gilles).
Enfin, suite aux nombreux cas d'hantavirose autour de la Belgique
en 2005, divers média ont parlé depuis lors des hantavirus
et de ce projet (JT Soir RTBF, Le Soir, La Libre
Belgique en 2005
et 2006,
La Capitale, METRO, VivaCité, BXL).
Projet de recherche financé par l'Institut d'encouragement
de la Recherche Scientifique et de l'Innovation de Bruxelles (IRSIB).
estimation and biological
control of human contamination risk in Brussels by
vole pathogens.
Rodent-borne
hantaviruses cause potentially deadly human infections
while reservoir species apparently remain symptom-free.
Various serotypes of these viruses are present from
Asia to America. In Europe, bank voles, Myodes
glareolus, are known to carry Puumala hantavirus and to transmit
haemorrhagic fever with renal syndrome to humans. This
is called nephropathia epidemica. Humans are probably
infected by inhalation of dust or aerosol contaminated
by vole dejections. This illness is exceptionally lethal.
The sympatric wood mice, Apodemus sylvaticus, usually
do not carry any hantavirus.
This
project
aims:
(1) To understand the mechanisms
of the spatial and temporal dynamics of hantavirus
infections in different rodent populations,
(2) To compare the spatial organisation
of healthy and infected animals, and
(3) To test the influence of predator
odours on vole movements during foraging.
Vole
densities and hantavirus presence (the seroprevalence) are
studied in the Soignes Forest (south of Brussels). Through
non-lethal captures, this work follows local variations
in spatial organisation and in the repartition of healthy
and infected animals.
Moreover, this study tests in the laboratory
the influence of predator odours on vole movements
inside a regular network of available routes (using
Ethovision software). It could be possible to biologically
control vole population movements through the use of such predator
odours. Such control could limit the risk of infection
and agricultural damage caused by some rodent species.
This
project lead to the diffusion of a leaflet for the
general public on animal-transmitted diseases (in French
and Dutch).
An information leaflet is also
available on the Scientific Institute of Public Health site (in
French
or Dutch),
which distributes the printed version of the brochure.
Finally consequently to the high number of hantaviroses around
Belgium in 2005, various local media mentioned hantaviruses and
this project (JT Soir RTBF, Le Soir, La Libre Belgique
in 2005
and 2006,
La Capitale, METRO, VivaCité, BXL).
Research
Project funded by the Brussels Capital Region (Institut d'encouragement
de la Recherche Scientifique et de l'Innovation de Bruxelles, (IRSIB).
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publications
pour usage personnel uniquement / for personnal
use only


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2011
Roelandt S., Heyman P., De Filette M., Vene S., Van der Stede Y., Caij A. B., Tavernier P., Dobly A., De Bosschere H., Vyt P., Meersschaert C. and Roels S. First tick-borne encephalitis virus (TBEV) seropositive dog discovered in Belgium: Screening of the canine population as sentinels for public health. Vector-Borne and Zoonotic Diseases, in press.
Dobly A., Cochez C., Goossens E., De Bosschere H., Hansen P., Roels S., Heyman P. Sero-epidemiological study of the presence of hantaviruses in domestic dogs and cats from Belgium. Research in Veterinary Science, in press.
2010
Dobly A., Langeveld J., van Keulen L., Rodeghiero C., Durand S., Geeroms R., Van Muylem P., De Sloovere J., Vanopdenbosch E., Roels S. No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older. BMC Veterinary Research 6:26.
2009
Roels S., Dobly A., De Sloovere J., Geeroms R. & Vanopdenbosch E. Listeria monocytogenes – associated meningo-encephalitis in cattle clinically suspected of bovine spongiform encephalopathy in Belgium (1998-2006). Flemish Veterinary Journal 78, 177-181.
Heyman P., Van Mele R., Smajlovic L., Dobly A., Cochez C., Vandenvelde C. Association between habitat and prevalence of hantavirus infections in bank voles (Myodes glareolus) and wood mice (Apodemus sylvaticus). Vector-Borne and Zoonotic Diseases 9, 141-146.
Dobly A. Breeding suppression between two unrelated and initially unfamiliar females occurs with or without social tolerance in common voles (Microtus arvalis). Journal of Ethology 27, 299-306, doi: 10.1007/s10164-008-0118-8.
2006
Tobin D., Kause A., Mäntysaan E.A., Martin S.A.M., Houlihan D.F., Dobly A., Kiessling A., Rungruangrak-Torrissen K., Ritola O. & Ruohonen K. Fat or lean? The quantitative genetic basis for selection strategies of muscle and body composition traits in breeding schemes of rainbow trout (Oncorhynchus mykiss). Aquaculture 261, 510-521.(pdf 163 Ko)
Kause A., Tobin D., Dobly A., Houlihan D. F., Martin S. A. M., Mäntysaari E., Ritola O. & Ruohonen K. Recording strategies and selection potential of feed intake measured using the X-ray method in rainbow trout. Genetics Selection Evolution 38, 389-409. (pdf 177 Ko)
2005
Dobly A. Scent-marking by common voles
(Microtus arvalis) in the presence of a same-sex
neighbour. Acta Theriologica 50, 343-356. (pdf
1624 Ko)
2004
Dobly A., Martin S.A.M., Blaney S.C., Houlihan
D.F. Protein growth rate in rainbow trout (Oncorhynchus
mykiss) is negatively correlated to liver 20S proteasome
activity. Comparative Biochemistry and Physiology Part
A 137(1), 75-85 (pdf
158 Ko)
2001
Dobly A. Movement patterns of male common
voles (Microtus arvalis) in a network of Y junctions:
role of distant visual cues and scent marks. Canadian
Journal of Zoology 79, 2228-2238. (pdf
790 Ko)
Dobly A., Rozenfeld F.M. & Haim A.
Effect of congeneric chemical signals of different
ages on foraging response and food choice in the field
by golden spiny mice (Acomys russatus). Journal
of Chemical Ecology 27(10), 1953-1961. (pdf
1077 Ko)
2000
Dobly A. & Rozenfeld F.M. Burrowing
by common voles (Microtus arvalis) in various
social environments. Behaviour 137(11), 1443-1462.
(pdf
241 Ko)
1999
Dobly A., Rozenfeld F.M. & Haim A.
Lack of neophobic response to trap in a diurnal rodent
the golden spiny mouse (Acomys russatus) from
an arid environment. Mammalia 63(2), 244-249.
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colloques
/ congress proceedings
* asterisks indicate oral presentations by A.
Dobly

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2010
Dobly A., Cochez C., Goossens E., De Bosschere H., Hansen P., Roels S. and Heyman P. Sero-epidemiological study of the presence of hantaviruses in domestic dogs and cats from Belgium. VIII International Conference on Hantaviruses, Athènes (Grèce), p. 121.
Dobly A., Cochez C. and Heyman P. Influence of hantavirus infections on individual spatial organization and population temporal dynamics in European forest rodents. VIII International Conference on Hantaviruses, Athènes (Grèce), p. 120.
2009
Guiet A., Dobly A., Fretin D. Goossens E., Govaerts M., Verheyden B., De Smedt C., Kiourtsidis D., Verdebout F., Detrain C., Tavernier P., Roels S. Sero-epidemiological study of four pathogens in cervids from Belgium and Norway. 3rd Symposium of the Belgian Wildlife Disease Society, Bruxelles (Belgique), p. 36.
Roels S., Dobly A., Renard C. & Vanopdebnbosch E. TSE epidemiosurveillance: methods and results. São Paulo (Brazil)
Dobly A., Renard C., Van Poucke M., Geeroms R., Durand S., Debrauwère D., De Sloovere J., Vanopdenbosch E. and Roels S. PRNP gene sequencing in Belgian goats. Prion 2009, Chalkidiki (Grèce)
2008
Dobly A., Rodeghiero C., Geeroms R., Durand S., De Sloovere J., Vanopdenbosch E. & Roels S. Biochemical screening for identification of atypical BSE in Belgium, 1999-present. Prion 2008, Madrid (Espagne), p. 125.
Tavernier P., Linden A., Pirot P., Heyman P., Dobly A. & Roels S. Improvement of wildlife disease surveillance in Belgium: the wildsurv project. 8th Conference of the European Wildlife Disease Association, Rovinj (Croatie), p. 90.
2007
Dobly A., Renard C., Willemarck N., Van Poucke M, De Sloovere J., Durand S., Geeroms R, Rodeghiero C., Vanopdenbosch E., Peelman L. & Roels S.. TSE surveillance in Belgian sheep. 13th Annual Symposium of the Belgian Society for Microbiology, Brussels (Belgium), p. 49.
* Dobly A. Rodent-borne hantaviruses: The ecology of an emerging zoonosis. 2nd Symposium of the Belgian Wildlife Disease Society, Brussels (Belgium), p. 21 (séance pléniaire).
Roels S., Heyman P., Dobly A., De Sloovere J., Durand S. & Vanopdenbosch E. Borna virus screening in wild mice in Belgium: preliminary data. 2nd Symposium of the Belgian Wildlife Disease Society, Brussels (Belgium), p. 31.
Heyman P., Van Mele R., Smajlovic L., Dobly A., Cochez C. & Vandenvelde C. Puumala hantavirus, Myodes glareolus and their habitat preferences. International Meeting on Emerging Diseases and Surveillance 2007, Vienne (Autriche), p. 67.
Dobly A., Renard C., Willemarck N., Van Poucke M, De Sloovere J., Durand S;, Geeroms R, Rodeghiero C., Vanopdenbosch E., Peelman L. & Roels S. Results of TSE surveillance in the Belgian sheep population. Prion 2007, Edinburgh (UK), p. 99.
2006
* Dobly A.
& Yzoard C. Movement patterns and foraging of bank voles in
a network of Y-junctions in presence of predator odours. 10th Rodens
et Spatium – The International Conference on Rodent Biology, Parma
(Italy), in press
Kause A., Tobin D., Dobly
A., Houlihan D.F., Martin S.A.M., Mäntysaari E. A., Ritola
O. & Ruohonen K. Recording long-term feed intake using X-ray
method in rainbow trout. 8th World Congress on Genetics Applied to Livestock
Production, Belo Horizonte (Brazil)
Kause A., Tobin D., Dobly
A., Houlihan D.F., Martin S.A.M., Mäntysaari E. A., Ritola
O. & Ruohonen K. Recording long-term feed intake using X-ray
method for selective breeding purposes in rainbow trout. 9th International
Symposium for Genetics in Aquaculture, Montpellier (France)
2005
Dobly A.,
Cochez C. & Heyman P. Hantavirus infection dynamics and spatial
organisation of bank voles and wood mice in southern Brussels. First Symposium
2004
* Dobly A., Cochez C. & Heyman P. Influence of
hantavirus infections on individual spatial organisation
and population temporal dynamics in European forest rodents.
10th International Behavioural Ecology Congress, Jyväskylä
(Finland), p. 50
2003
Wahlroos
H., Dobly A., Kause A., Ritola O., Mantysaari E., Ruohonen
K. & Houlihan D.F. Finland genetic parameters
for growth and food intake in rainbow trout. Genetics
in Aquaculture VIII, Pto Varas (Chili), p. 88
Dobly
A., Ritola O., Wahlroos H., Kause A., Mäntysaari E.,
Ruohonen K., Martin S.A.M. & Houlihan D.F.
Genetic correlates of protein growth efficiency
in 210 families of rainbow trout assessed by X-rays.
Genetics in Aquaculture VIII, Pto Varas (Chili), p. 118.
Poster
2001
* Dobly A. Role of scent-marks and distant visual cues
in movement patterns of common voles (Microtus arvalis). 8th
International Theriological Congress, Sun City (South
Africa), p. 52
1999
*
Dobly A. Impact du lien de parenté sur la reproduction
et la socialité des femelles de campagnols.
Premier Congrès de l'Association Francophone
pour l'Ethologie, l'Ecologie et l'Evolution, Rennes
(France), p. 25
* Dobly A. Kinship influences reproduction and social
behaviour of paired female voles. XXVI International Ethological
Conference, Bangalore (India), p. 196. Poster with
plenary oral presentation
* Dobly A., Rozenfeld F.M. & Haim A. Influence of heterospecific
odours on feeding behaviour under field conditions
in a diurnal rodent, the golden spiny mouse (Acomys russatus).
8th African Small Mammals International Symposium,
Paris (France), p. 67
1998
Rozenfeld
F.M., De Jaegere F. & Dobly A. Social environment
in relation with the reproductive success of females
in two vole species. International Conference on Rodent
Biology and Management, Beijing (China), pp. 67-68
* Dobly A. & Rozenfeld F.M. Do female common voles cooperate
in burrowing? Euro-American Mammal Congress, Santiago
de Compostela (Spain), p. 260
1997
Rozenfeld
F.M. & Dobly A. Pheromones in spacing behaviour
and reproductive success of female voles. Advances
in Ethology 32, Contributions to the XXV International
Ethological Conference, Vienna (Austria), p. 35
1996
* Dobly A. & Rozenfeld F.M. Impact des interactions
sociales sur la structuration du terrier chez le campagnol des
champs, Microtus arvalis (Mammalia, Rodentia). Congrès
International Francophone sur le Comportement Animal, Quebec
(Canada), p. 21
1994
* Dobly A. Digging behaviour and social interactions
in the common vole (Microtus arvalis). First Benelux-Congress
of Zoology, Leuven (Belgium), p. 110
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