Selected publications of Prof. Chantal Mathieu 

1. Gysemans, C.A., Cardozo, A.K., Giulietti, A., Callewaert, H., Hulshagen, L., Bouillon, R., Eizirik, D.L. and C. Mathieu. (2005) 1,25-dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in NOD mice. Endocrinology 146:1956-1964. [PubMed]

2. Decallonne, B., van Etten, E., Overbergh, L., Valckx, D., Bouillon, R. and C. Mathieu. (2005) 1,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells. J Autoimmun 24: 281-289.  [PubMed]

3. Keymeulen, B., Vandemeulebroucke, E., Ziegler, A.G., Mathieu, C., Kaufman, L., Hale, G., Gorus, F., Goldman, M., Walter, M, Candon, S., Schandene, L., Crenier, L., De Block, C., Seigneurin, J.M., De Pauw, P., Pierard, D., Weets, I., Rebello, P., Bird, P., Berrie, E., Frewin, M., Waldmann, H., Bach, J.F., Pipeleers, D. and L. Chatenoud. (2005) Insulin needs following CD3 antibody therapy in new-onset type 1 diabetes. New Engl J Med 352:2598-608.  [PubMed]

4. Gysemans, C.A., Ladrière, L., Callewaert, H., Rasschaert, J., Flamez, D., Levy, D.E., Matthys, P., Eizirik, D.E. and C. Mathieu. (2005) Disruption of the IFN-gamma signaling pathway at the level of STAT-1 prevents immune destruction of beta-cells. Diabetes 54:2396-403.   [PubMed]

5. Rasschaert, J., Ladrière, L., Urbain, M., Dogusan, Z., Katabua, B., Sato, S., Akira, S., Gysemans, C., Mathieu, C. and D.L. Eizirik. (2005) Toll-like receptor 3 and STAT-1 contribute for dsRNA+IFNgamma-induced apoptosis in primary pancreatic beta-cells. J Biol Chem 280:33984-33991. [PubMed]

6. Stoffels, K., Overbergh, L., Giulietti, A., Verlinden, L., Bouillon, R. and C. Mathieu. (2006) Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res 21:37-47. [PubMed]

7. Overbergh, L., Stoffels, K., Waer, M., Verstuyf, A., Bouillon, R., and C. Mathieu. (2006) Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction. J Clin Endocrinol Metab 91:3566-3574. [PubMed]

8. Huurman, V.A., Decochez, K., Mathieu, C., Cohen, I.R., and B.O. Roep (2006) Therapy with the hsp60 peptide DiaPep277(trade mark) in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 23:269-275. [PubMed]

9. Keymeulen, B., Gillard, P., Mathieu, C., Movahedi, B., Maleux, G., Delvaux, G., Ysebaert, D., Roep, B., Vandemeulebroucke, E., Marichal, M., In ’t Veld, P., Bogdani, M., Hendrieckx, C., Gorus, F., Ling, Z., van Rood, J., and D. Pipeleers. (2006) Correlation between beta-cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. P Natl Acad Sci USA 103:17444-17449.  [PubMed]

10. Matricali, G.A., Dereymaeker, G., Muls, E., Flour, M., and C. Mathieu. (2007) Economic aspects of diabetic foot care in a multidisciplinary setting: a review. Diabetes Metab Res Rev 83:245-246. [PubMed]

11. Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., and C. Mathieu. (2007) Monocytes from type 2 diabetic patients have a pro-inflammatory profile 1,25-dihydroxyvitamin D3 works as anti-inflammatory. Diabetes Res Clin Pract. 77:47-57. [PubMed]

12. van Etten, E., Verlinden, L., Giulietti, A., Ramos Lopez, E., Branisteanu, D.D., Bomfim Ferreira, G., Overbergh, L., Verstuyf, A., Bouillon, R., Roep, B.O., Badenhoop, K. and C. Mathieu. (2007) The vitamin D receptor gene FokI polymorphism: functional impact on the immune system Eur J Immunol 37:395-405. [PubMed]

13. Matricali, G.A., Bammens, B., Kuypers, D., Flour, M., and C. Mathieu. (2007) High rate of Charcot foot attacks early after simultaneous pancreas-kidney transplantation. Transplantation 83:245-246. [PubMed]

14. Callewaert, H.I., Gysemans, C.A., Ladriere, L., D'Hertog, W., Hagenbrock, J., Overbergh, L., Eizirik, D.L., and C. Mathieu. (2007) Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection. Diabetes 56:2169-2173. [PubMed]

15. Boonen, K., Baggerman, G., D'Hertog, W., Husson, S.J., Overbergh, L., Mathieu, C., and L. Schoofs. (2007) Neuropeptides of the islets of Langerhans: a peptidomics study. Gen Comp Endocrinol 52:231-241. [PubMed]

16. Callewaert, H., Gysemans, C., Cardozo, A.K., Elsner, M., Tiedge, M., Eizirik, D.L., and C. Mathieu. (2007) Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes. Cell Transplant 16:527-537. [PubMed]

17. Driver, J.P., Foreman, O., Mathieu, C., van Etten, E. and D.V. Serreze (2007) Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D3 and 1alpha-hydroxyvitamin D3 on type-1 diabetes in NOD mice fed a normal-calcaemic diet. Clin Exp Immunol, In Press.

18. D’Hertog, W., Overbergh, L., Lage, K., Ferreira, G.B., Maris, M., Gysemans, C., Flamez, D., Cardozo, A.K., Van den Bergh, G., Schoofs, L., Arckens, L., Moreau, Y., Hansen, D.A., Eizirik, D.L., Waelkens, E., and C. Mathieu. (2007) Proteomic analysis of cytokine-induced dysfunction and death in insulin producing INS-1E cells: new insights into the pathways involved. Mol Cell Proteomics, In Press.

19. Gillard, P., Ling, Z., Mathieu, C., Crenier, L., Lannoo, M., Maes, B., Roep, B., Gorus, F., Pipeleers, D., and B. Keymeulen (2007) Comparison of sirolimus alone with sirolimus plus tacrolimus in type 1 diabetic recipients of cultured islet cell grafts. Transplantation, In Press.

20. Gysemans, C., van Etten, E., Overbergh, L., Giulietti, A., Eelen, G., Waer, M., Verstuyf, A., Bouillon, R., and C. Mathieu (2007) Unaltered disease presentation in NOD mice lacking the vitamin D receptor. Diabetes, In Press.