Selected publications of Prof. Timo Otonkoski

 

1. Ylipaasto P, Kutlu B, Rasilainen S, Rasschaert J, Teerijoki H, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otonkoski T, Roivainen M: Global profiling of coxsackievirus- or cytokine- induced gene expression in human pancreatic islets. Diabetologia 48:1510-1522, 2005. [PubMed]

2. Skottman H, Mikkola M, Lundin K, Olsson C, Tuuri T, Otonkoski T, Hovatta O, Lahesmaa R: Gene expression signatures of seven genetically independent human embryonic stem cells lines. Stem Cells 23:1343-1356, 2005. [PubMed]

3. Geutskens SB, Otonkoski T, Pulkkinen M-A, Drexhage HA, Leenen PJM: Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro. J. Leukocyte Biol 78:845-852, 2005. [PubMed]

4. Hermann R, Mantere J, Lipponen K, Veijola R, Soltesz G, Otonkoski T, Simell O, Knip M, Ilonen J: Lack of association of Pax4 gene with type 1 diabetes in the Finnish and Hungarian populations. Diabetes, 54:2816-2819, 2005. [PubMed]

5. Gao R, Ustinov J, Korsgren O, Otonkoski T: In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia, 48:2296-2304, 2005. [PubMed]

6. Otonkoski T, Näntö-Salonen K, Seppänen M, Veijola R, Huopio H, Hussain K, Tapanainen P, Eskola O, Parkkola R, Ekström K, Guiot Y, Rahier J, Rintala R, Nuutila P, Minn H: Noninvasive diagnosis of focal persistent hyperinsulinism of infancy with 18F- dopa positron emission tomography. Diabetes 55:13-18, 2006. [PubMed]

7. Mikkola M, Olsson C, Palgi J, Ustinov J, Palomäki T, Horelli-Kuitunen N, Knuutila S, Lundin K, Otonkoski T, Tuuri T: Distinct differentiation characteristics of individual human embryonic stem cell lines. BMC Developmental Biology 6:40, 2006. [PubMed]

8. Miettinen PJ, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, Juntti-Berggren L, Berggren P-O, Otonkoski T: Downregulation of EGF receptor signalling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes 55:3299-3308, 2006. [PubMed]

9. Heiskanen AM, Satomaa T, Tiitinen S, Laitinen A, Mannelin S, Mikkola M, Olsson C, Miller-Podraza H, Blomqvist M, Olonen A, Lehenkari P, Tuuri T, Otonkoski T, Natunen J, Saarinen J, Laine J: N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is reversible. Stem Cells 25:197-202, 2007. [PubMed]

10. Gao R, Ustinov J, Korsgren O, Mikkola M, Lundin K, Otonkoski T: Maturation of in vitro-generated human islets after transplantation in nude mice. Mol Cell Endocrinol 264:28-34, 2007. [PubMed]

11. Gao R, Ustinov J, Korsgren O, Otonkoski T: Effects of immunosuppressive drugs on in vitro neogenesis of human islets. Am J Transp. 7:1021-1026, 2007. [PubMed]

12. Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipilä I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA and Kere J: Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet 81:467-74, 2007. [PubMed]

13. The International Stem Cell Initiative (ISCI): Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnology 25: 803-816, 2007. [PubMed]

14. Otonkoski T, Gao R, Lundin K: Stem cells in the treatment of diabetes. Ann Med 37:513-520, 2005. [PubMed]

15. Otonkoski T, Banerjee M, Lundin K: Stem cells as a cure for diabetes. Chapter 14 in: Seino S (Ed) Pancreatic beta cell in health and disease. Springer, Tokyo. pp. 259-278, 2007.

16. Hanley NA, Piper Hanley K, Miettinen P, Otonkoski T: Weighing up beta cell mass in mice and humans: self renewal, progenitors or stem cell? Molecular and Cellular Endocrinology, in press