Selected publications of Prof. Decio Eizirik

 

1. Cardozo AK, Ortis F, Storling J, Feng Y-M, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL Cytokines downregulate the sarcoendoplasmic-reticulum pump Ca2+-ATPase (SERCA)2b and deplete endoplasmic reticulum (ER)-Ca2+ leading to induction of ER-stress in pancreatic beta-cells. Diabetes, 54: 452-461, 2005. [PubMed ]

2. Elouil HE, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC High glucose and hydrogen peroxide stimulate c-Myc and heme-oxygenease 1 mRNA expression in rat pancreatic islets without activating NF-kappaB. Diabetologia, 48: 496-505, 2005. [PubMed ]

3. Smink LJ, Helton EM, Healy BC, Cavnor C, Lam AC, Flamez D, Burren OS, Wang Y, Dolman GE, Burdick DR, Everett VH, Glusman G, Laneri D, Rowen L, Schuilenburg H, Walker NM, Mychaleckyj J, Wicker LS, Eizirik DL, Todd JA, Goodman N. T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acid Research, 33:D544-549, 2005. [PubMed ]

4. Gysemans CA, Cardozo AK, Giulietti A, Hulshagen L, Bouillon R, Eizirik DL, Mathieu C 1,25 Dihidroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of type 1 diabetes in NOD mice. Endocrinology, 146: 1956-1964, 2005. [PubMed ]

5. Gysemans C, Ladriere L, Callewaert H, Rasschaert J, Flamez D, Levy D, Matthys P, Eizirik DL, Mathieu C Disruption of the IFN-gamma signaling pathway at the level of STAT-1 prevents immune destruction of beta-cells. Diabetes, 54: 2396-2403, 2005. [PubMed ]

6. Ylipaasto P, Kutlu B, Raisilainen S, Rasschaert J, Teerijoki T, Korsgren O, Lahesmaa R, Hovi T, Eizirik DL, Otokonski T, Roivainen M Global profiling coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia, 48: 1510-1522, 2005. [PubMed ]

7. Rasschaert J, Ladriere L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL Toll-like receptor 3 and STAT-1 contribute for dsRNA + IFN-gamma-induced apoptosis in pancreatic beta-cells. J Biol Chem 280:33984-33991, 2005. [PubMed ]

8. Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes 54: 3238-3244, 2005. [PubMed ]

9. Cnop M, Welsh N, Jonas J-C, Jorns A, Lenzen S, Eizirik DL Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes, 54 (Suppl. 2): S97-S107, 2005. [PubMed ]

10. Larsen L, Størling J, Eizirik DL, Billestrup N, Mandrup-Poulsen T Extracellular signal-regulated kinase is essential for interleukin-1beta mediated and nuclear factor-kappaB-mediated gene expression in insulin producing INS-1 cells. Diabetologia, 48: 2582-2590, 2005. [PubMed ]

11. Magnusson NE, Cardozo AK, Kruhoffer M, Eizirik DL, Ortonft FT, Jensen JL Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis. BMC Bioinformatics 6:311-23, 2005. [PubMed ]

12. Darville MI, Eizirik DL Notch signaling: a mediator of beta-cell de-differentiation in diabetes? Biochem Biophys Res Commun 339: 1063-1068, 2006. [PubMed ]

13. Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Christoferi G, Ben-Neriah Y, Carel JC, Boitard C, Klein T, Serup P, Eizirik DL, Melloul D Conditional and specific NF-kappaB blockade protects pancreatic beta cells against diabetogenic inducers. Proc Natl Acad Sci USA 103: 5072-5077, 2006. [PubMed ]

14. Pirot P, Eizirik DL, Cardozo AK Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing beta cell defense mechanisms. Diabetologia, 49: 1229-1236, 2006. [PubMed ]

15. Ortis F, Cardozo AK, Crispim D, Storling J, Mandrup-Poulsen T, Eizirik DL Cytokine-induced pro-apoptotic gene expression in insulin-producing cells is related to rapid, sustained and non-oscillatory NF-kappaB activation. Mol Endocrinol 20: 1867-1879, 2006. [PubMed ]

16. Kharroubi I, Lee CH, Hekerman P, Darville MI, Evans RM, Eizirik DL, Cnop M BCL-6: a possible missing link for anti-inflammatory PPAR-? signaling in pancreatic beta cells. Diabetologia, 49:2350-2358, 2006. [PubMed ]

17. Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Flamez D, Boyce M, Yuang J, Eizirik DL Selective inhibition of eIF2alpha dephosphorylation potentiates fatty acid-induced ER stress and causes pancreatic?beta-cell dysfunction and apoptosis. J Biol Chem, 282: 3989-3997, 2007. [PubMed ]

18. Hulbert EM, Smink LJ, Adlem EC, Allen J, Burdick DB, Burren OS, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, Walker NM, Mychaleckyj J, Eizirik DL, Wicker LS, Todd JA, Goodman N. T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res, 35(Database issue):D742-746, 2007. [PubMed ]

19. Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK Transcriptional regulation of the endoplasmic reticulum (ER) stress gene Chop in pancreatic insulin producing cells. Diabetes, 56:1069-1077, 2007. [PubMed ]

20. Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C Cell loss during pseudo-islet formation hampers profound impairments in islet lentiviral transduction efficacy for transplantation purposes. Cell Transplant, 16:527-537, 2007. [PubMed ]

21. Pirot P, Naamane N, Libert F, Magnusson NE, Ørtonft TF, Cardozo AK, Eizirik DL Global profiling of endoplasmic reticulum (ER) stress modified genes in pancreatic beta cells unveils an early degradation of insulin mRNA. Diabetologia, 50:1006-1014, 2007. [PubMed ]

22. Naamane N, van Helden J, Eizirik DL In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells. BMC Bioinformatics, 8:55, 2007. [PubMed ]

23. Callewaert HI, Gysemans CA, Ladriere L, D’Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C Deletion of STAT-1 in pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection. Diabetes, 56: 2169-2173, 2007. [PubMed ]

24. Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Manighetti A, Melaïm L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, and Maurer F Cell-permeable peptides induce cytotoxicity in pancreatic ß cells. Biochim Biophys Acta 1768: 2222-2234, 2007. [PubMed ]

25. Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M The endoplasmic reticulum in pancreatic beta-cells of type 2 diabetes patient. Diabetologia, “in press”, 2007 (Sep 30; [Epub ahead of print]). [PubMed ]

26. D’Hertog W, Overbergh L, Lage K, Ferreira G, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C Proteomic analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved. Mol Cell Proteomics “in press” (Oct 5; [Epub ahead of print]). [PubMed ]